Light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice

Al-Ani, Imad Matloub Dally and Noor Al-Deen, Jinan A. and Kashmola, Muhanad Ali Hamdon (2008) Light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice. In: 17th EMSM Scientific Conference and 18th Annual General Meeting, 18-20 Dec. 2008, Holiday Inn Glenmarie, Shah Alam, Kuala Lumpur.

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Abstract

Light microscopic (LM) and transmission electron microscopic (TEM) observations were performed in the kidneys of oral contraceptive treated mice. Experimental groups were given 0.1 ml of olive oil containing 0.015 fraction of (Neogynon) tablet daily. Control groups were give olive oil alone.Five experimental and three control animals were scarified after 1,3,6,9,and 12 estrus cycles. Glomerulosclerosis,hyaline arteriopathy associated with focal areas of interstitial fibrosis were observed in the first cycle. Mild hypertrophy of juxtaglomerular apparatus “JGA” appeared in the 3rd cycle with increased granularity of the JGCs. Proliferative-sclerosing stages of focal glomerulonephritis were observed and were more advanced in cycle twelve.By transmission electron microscope, there were slight changes in the glomeruli during cycle one. These evident gradually developed in cycle three, thus the glomeruli showed disordered capillary loop occlusion. In cycle six, capillary lumens were occluded by protuberance projection. There were hyperactivity and proliferation of mesangial cells and electron-dense material deposits in glomerular basal lamina; these deposits were accompanied with electron-lucent materials appeared in cycle 9 behind swelled mesangial cells indicating hyperactivity and proliferative cells which showed abundant RER and mitochondria. These lesions were correlated with hyper-granularityof JGCs and hypertrophied JGA. The JGGs appeared in cycle 12 as heterogenized size. These changes indicate that abuse of oral contraceptives is relatively unsafe, especially after long-term of high-do

Item Type:	Conference or Workshop Item (Speech/Talk)
Additional Information:	5849/24876
Uncontrolled Keywords:	LM, TEM, contraceptives, juxtaglomerular apparatus
Subjects:	R Medicine > RG Gynecology and obstetrics R Medicine > RM Therapeutics. Pharmacology > RM300 Drugs and their action
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Dentistry
Depositing User:	Assoc. Prof Dr.. Imad Matloub Dally Al-Ani
Date Deposited:	27 Mar 2014 09:52
Last Modified:	18 Dec 2015 10:50
URI:	http://irep.iium.edu.my/id/eprint/24876

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