Scaling-up the production of 13s-hydroxy-9Z,11E-octadecadienoic acid (13S-HODE) through chemoenzymatic technique

Omar, Muhammad Nor and Moynihan, Humphrey and Hamilton, Richard J. (2003) Scaling-up the production of 13s-hydroxy-9Z,11E-octadecadienoic acid (13S-HODE) through chemoenzymatic technique. Bulletin of Korean Chemical Society, 24 (3). pp. 397-399. ISSN 0253-2964

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Abstract

In spite of greater use of oils and fats in the food industry, the other applications have not been explored very much. Beside the oleochemical industry, the other areas that attract greater interest nowadays are the utilization of fatty acids and their derivatives in pharmaceutical applications. While most fatty acids are achiral molecules, this lack of chirality becomes a great challenge to the chemists to look into possibilities of transforming them into highly value-added chiral molecules which exhibit a vast variety of biological roles in plants and mammals. The most popular technique to transform achiral fatty acids into their corresponding chiral metabolites is through biotechnology processes.1 With the increasing demands for microbial and enzymatic biotransformation, the search for new biologically active substances has been given great attention. In the case of linoleic acid 1, the enzyme which can transform the acid into a chiral hydroperoxide, i.e. 13S-hydroperoxy-9Z,11E-octadecadienoic acid (13S-HPOD, 2) is called lipoxygenase (LOX). 13SHPOD is a precursor for the formation of 13S-hydroxy-9Z,11E-octadecadienoic acid (13S-HODE, 3) (Scheme 1).

Item Type:	Article (Journal)
Additional Information:	5626/24441
Uncontrolled Keywords:	Scale-up, 13S-HODE, Chemoenzymatic technique
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Biotechnology
Depositing User:	Prof Dr Muhammad Nor Omar
Date Deposited:	13 Aug 2012 12:54
Last Modified:	13 Aug 2012 12:54
URI:	http://irep.iium.edu.my/id/eprint/24441

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