Mammographic breast density : is there any association with positive family history of breast cancer?

Muhammed Nordin, Ellyda and Mohd Rus, Razman and Che Mohamed, Siti Kamariah and Hassan, Radhiana (2012) Mammographic breast density : is there any association with positive family history of breast cancer? In: College of Radiology Scientific Meeting 2012; Cancer Imaging, 30th March-1st April 2012, Equtorial Hotel, Penang. (Unpublished)

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Abstract

INTRODUCTION: Breast cancer is the commonest overall cancer as well as the commonest cancer in women amongst all races. A higher incidence of breast cancer has been reported in women with dense breast parenchyma visible on mammogram and individuals with a family history of cancer. Previous study has reported that women with a family history of breast cancer tend to have dense breasts and this partially explains their increased risk of breast cancer. OBJECTIVES: The aim of this study was to determine the distribution of mammographic density using Tabar classification and association between mammographic density and family history of breast cancer. METHODOLOGY: A retrospective review of data collected from women presenting for screening mammogram at IIUM Breast Centre from January 2008 until December 2009. A total of 506 subjects fulfilled the inclusion criteria. Both cranio-caudal and medio-lateral oblique views were reviewed on the BARCO monitor and the mammographic densities were classified by the interpreting radiologist, using Tabar’s classification system. Family history of breast cancer was defined as having at least one first degree relative (parent, sibling or child) with breast cancer. RESULTS: Out of 506 patients participated, 43.3% of the patients belong to Tabar pattern I; 19.6% Tabar pattern IV; 17.8% Tabar pattern II; 16.8% Tabar pattern III and 2.6% Tabar pattern V. Our result also revealed a significant association between mammographic density and positive family history of breast cancer (p= 0.006). CONCLUSION These results show the population variation in the percentage of dense tissue on mammography and women with higher breast density were more likely to have positive family history of breast cancer. Thus, the genetic factors that determine breast density may determine breast cancer risk.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	4532/23374
Uncontrolled Keywords:	breast cancer, mammography, family history
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Community Medicine (Effective: 1st January 2011) Kulliyyah of Medicine > Department of Radiology
Depositing User:	Dr Ellyda Muhammed Nordin
Date Deposited:	08 Aug 2012 11:27
Last Modified:	08 Aug 2012 11:27
URI:	http://irep.iium.edu.my/id/eprint/23374

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