In vitro elution and dissolution of tobramycin and gentamicin from calcium phosphate

Che Seman, Che Nor Zarida and Othman, Fauziah and Abdul Kadir, Arifah and Ahmad, Azfar Rizal and Mohd Yusof, Nazri and Zulkifly, Ahmad Hafiz and Mustaffa, Rusnah and Goriman Khan, Mohd Azam Khan and Saidi, Hasni Idayu (2011) In vitro elution and dissolution of tobramycin and gentamicin from calcium phosphate. African Journal of Pharmacy and Pharmacology, 5 (20). pp. 2283-2291. ISSN 1996-0816

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Abstract

This study was conducted to investigate the in vitro drug release characteristics of tobramycin and gentamicin from calcium phosphate. Calcium phosphate beads were loaded with tobramycin and gentamicin separately to form 2 types of antibiotic beads to generate antibiotic drug delivery system for the treatment of osteomyelitis. Tobramycin and gentamicin concentrations were determined spectrophotometrically by measuring the absorbance at 400 nm. The standard graphs for tobramycin and gentamicin concentration versus absorbance reading were prepared as references to identify the concentration of the drugs release after incorporating calcium phosphate over 8 weeks. This study showed that incorporating tobramycin and gentamicin with calcium phosphate provided slow residual release of antibiotic from 30 min to 1344 h (8 weeks) and dissolution of calcium phosphate. In this respect, the drug delivery systems of tobramycin and gentamicin-incorporated calcium phosphate have potential of controlling drug release.

Item Type:	Article (Journal)
Additional Information:	2397/21782
Uncontrolled Keywords:	Tobramycin, gentamicin, calcium phosphate, drug delivery system, osteomyelitis.
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation
Depositing User:	Prof Dr Ahmad Hafiz Zulkifly
Date Deposited:	07 Mar 2012 16:34
Last Modified:	13 Jan 2015 14:47
URI:	http://irep.iium.edu.my/id/eprint/21782

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