Process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes.

Abu Bakar, Mohd Rushdi and Nagy, Zoltan K. (2011) Process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes. In: Current Issues in Pharmacy. IIUM Press, Kuala Lumpur , pp. 129-155. ISBN 9789674180195

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Abstract

Crystallization is an important unit operation used in a variety of industries. Its importance in the pharmaceutical industries is due to a large number of active pharmaceutical ingredients that are utilised in solid form. It is estimated that more than 80% ofpharmaceutical products involve at least one crystallization step in their manufacturing process (Reutzel-Edens, 2006). The pharmaceutical crystallisation operation is often critical because it determines the product properties, such as the crystal size distribution, morphology and polymorphic form. These properties in tum influence the efficiency of the subsequent downstream operations, particularly filtration and drying. The properties also affect the therapeutic performance ofthe product, such as dissolution rate and bioavailability. A proper control of crystallization processes offers possibilities for improved process efficiency and better product quality

Item Type:	Book Chapter
Additional Information:	4033/18493
Uncontrolled Keywords:	Pharmaceutical crystallisation
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr Mohd Rushdi Abu Bakar
Date Deposited:	27 Aug 2012 15:24
Last Modified:	27 Aug 2012 15:24
URI:	http://irep.iium.edu.my/id/eprint/18493

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