Computational investigation on CSF flow analysis in the third ventricle and aqueduct of sylvius

Hadzri, Edi Azali and Abdul Ghani, Ahmad Lufti and Shamsuddin, Amir Hamzah and Osman, Kahar and Abdul Kadir, Mohammed Rafiq and Abd. Aziz, Azian (2011) Computational investigation on CSF flow analysis in the third ventricle and aqueduct of sylvius. IIUM Engineering Journal, 12 (3). pp. 133-142. ISSN 1511-788X

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Abstract

In this study, a three dimensional (3D) model of the third ventricle and aqueduct of Sylvius derived from MRI scans was constructed by using Computational Fluid Dynamics (CFD) modeling. Cerebrospinal fluid(CSF) can be modeled as a Newtonian Fluid and its flow through the region of interest (ROI) was visualized using Engineering Fluid Dynamics (EFD).The constructed ROI was regarded as rigid walled and only steady state flow was able to be defined due to the limitations of current software. Different flow rate was simulated at the Foramen of Monro and a small stenosis was modeled at the middle of the aqueduct of Sylvius at a fixed location. This was made corresponding to normal patients with variation of CSF flow rate physiologically and abnormal patients with tumor causing obstruction to or within the aqueduct of Sylvius, respectively. Due to the small dimensions of the ROI geometry, gravity and complex external gravity that acted upon it was considered to be neglected. The results show as the flow rate increase, the pressure drop of CSF in the ROI proportionally increased. For normal CSF flow rate, the presence of stenosis in the aqueduct demonstrates a significant increased pressure drop.

Item Type:	Article (Journal)
Additional Information:	5267/14201
Uncontrolled Keywords:	cerebrospinal fluid; CFD; magnetic resonance image; human ventricular system
Subjects:	T Technology > TA Engineering (General). Civil engineering (General) > TA164 Bioengineering
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Radiology
Depositing User:	Prof. Dr. Azian Abd. Aziz
Date Deposited:	30 Jan 2012 10:00
Last Modified:	26 Apr 2013 18:41
URI:	http://irep.iium.edu.my/id/eprint/14201

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