Resveratrol: delivery problems and nano/micro formulations

Dutta, Koustav and Sravani, T and Shivaprasad, H N and Mondal, Sumanta and Das, Suvadra and Roy, Partha and Abd Aziz, Zul Hadif and Helal Uddin, A.B.M. (2026) Resveratrol: delivery problems and nano/micro formulations. In: Pleiotropic Phytochemicals. Cambridge Scholars Publishing, UK, pp. 144-181. ISBN 978-1-0364-6240-6

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Abstract

Resveratrol is a natural polyphenol that is present in peanuts, berries, and grapes and has put extensive research into its health benefits. It has been granted a promising therapeutic agent due to its neuroprotective, antioxidant, anti-inflammatory, cardioprotective, and anticancer properties. Low bioavailability, quick metabolism, and a low level of water solubility are serious biopharmaceutical problems impeding the clinical use of resveratrol. Once taken orally, it is widely metabolized in the intestines and the liver causing low absorption of the system and low therapeutic efficacy. Efforts have been made to defeat these hurdles by researchers focusing on developed drug delivery principles, particularly, nano- and micro- formulations. Resveratrol: Delivery Problems and Nano/Micro Formulations 145 Polymeric nanoparticles, solid lipid carriers, liposomes and nanoparticles have all proved themselves as viable in enhancing stability, solubility, and bioavailability of resveratrol. These technologies increase the medicinal use of resveratrol by medication as a controlled release, targeted, or better absorption. Nanoparticle formulations greatly enhance bioavailability over the traditional ones and also microencapsulation increases its shelf life by defending against degradation by the environment. The reviewed paper brings to light the key biopharmaceutical issues surrounding resveratrol and will present the latest advances in nanotechnology-based delivery vehicles. These issues can be addressed to unlock the full potential of resveratrol in treatment, and will pave the path of its extensive clinical use in the treatment or management of chronic diseases commencing with cancer, neurodegeneration and cardiovascular illnesses. Future research should aim at enhancing the systems in order to ensure scalability, safety and efficacy of these delivery systems in the clinical setting.

Item Type:	Book Chapter
Uncontrolled Keywords:	Keywords: Nanotechnology, antioxidants, microencapsulation, resveratrol, pharmacokinetics, polyphenols
Subjects:	Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr. A. B. M. Helal Uddin
Date Deposited:	29 Sep 2026 15:17
Last Update:	29 Sep 2026 15:17
Queue Number:	2026-09-Q5309
URI:	http://irep.iium.edu.my/id/eprint/131558
Indexed In:	UNSPECIFIED

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