Anti-gout potential of traditional medicinal plants enriched with flavonoids: a systematic review

Fitri Suhaimi, Nurul Shahira and Begum, Taslima and Ali Shah, Syed Adnan and Helal Uddin, A.B.M. and Zakaria, Zainul Amiruddin and Ahmed, Qamar Uddin (2026) Anti-gout potential of traditional medicinal plants enriched with flavonoids: a systematic review. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 25 (2). pp. 147-176. ISSN 0717-7917

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Abstract

The global prevalence of gout is increasing, with current pharmacological treatments often proving inadequate or causing adverse effects, especially in chronic cases. This has spurred interest in safer, natural alternatives. Flavonoids found in fruits, vegetables, and herbs exhibit antigout potential through xanthine oxidase (XO) inhibition, uric acid reduction, and anti-inflammatory effects. This review evaluates the pharmacological potential of flavonoid-rich traditional medicinal plants for gout treatment, analyzing in vivo, in vitro, and in silico studies from 2003 to 2023. Using the QuADS tool, 30 articles on 18 plant species were assessed. The findings reveal that flavonoids demonstrate significant antigout activity, particularly via XO inhibition and inflammation modulation. Promising in vivo results were observed in rodent models, despite variability in flavonoid concentration and formulation. Blumea balsamifera, Chrysanthemum sinense, Gnaphalium affine, Kaempferia parviflora, Perilla frutescens and luteolin stood out for their consistent efficacy. These insights support further research into flavonoids as natural agents for gout management.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Gout; Medicinal plants; Flavonoids; Xanthine oxidase inhibitory effect; Anti-gout effect
Subjects:	Q Science > QD Chemistry R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr Qamar Uddin Ahmed
Date Deposited:	05 Mar 2026 09:27
Last Modified:	05 Mar 2026 09:27
Queue Number:	2026-03-Q2441
URI:	http://irep.iium.edu.my/id/eprint/127777

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