Prevalence and perinatal outcomes of group B streptococcus positive mothers in a University Hospital in Pahang, Malaysia

Yusof, Nurul Mutmainnah and Nusee, Zalina and Mohd Yusoff, Mohd Azam and Abd. Aziz, Karimah Hanim (2025) Prevalence and perinatal outcomes of group B streptococcus positive mothers in a University Hospital in Pahang, Malaysia. IIUM Medical Journal Malaysia, 24 (01). pp. 128-134. ISSN 1823-4631 E-ISSN 2735-2285

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Abstract

INTRODUCTION: Group B streptococcus (GBS) is a leading cause of early neonatal infection and is related to various maternal infections. This study aims to determine the prevalence of GBS-positive mothers and their pregnancy outcomes in a University Hospital in Pahang, Malaysia. MATERIALS AND METHODS: A comparative cross-sectional study was conducted from October 2021-May 2022, involving 230 pregnant women between 35-38 weeks follow-up at this hospital. Rectovaginal swab (RVS), high vaginal swab (HVS), and midstream urine (MSU) cultures were sent for GBS screening in asymptomatic mother, and positive mothers received intrapartum antibiotic prophylaxis (IAP) as per protocol. Maternal outcome analysed were preterm pre-labour rupture of membrane (PPROM), preterm labour, maternal pyrexia, and puerperal infection. Whereas, neonatal outcomes include prematurity, low Apgar score, requirements of NICU/SCN admission and antibiotic; and diagnosis of neonatal early-onset GBS (EOGBS) disease. RESULTS: 58.6% of participants were tested GBS-positive based on either RVS, HVS, or MSU culture. There was no significant association between maternal GBS status, sociodemographic, and clinical background except for being overweight (mean BMI 26.3 kg/m2, p= 0.047). Maternal and neonatal outcomes were not significantly different between GBS-positive and GBS-negative mothers. CONCLUSION: The prevalence of GBS colonisation (58.6%) was higher compared to reports worldwide. However, the implementation of GBS screening and IAP had successfully prevented the development of EOGBS disease and complication for both mothers and neonates. Therefore, screening for asymptomatic mother is important and effective for GBS infection

Item Type:	Article (Journal)
Uncontrolled Keywords:	Group B Streptococcus, Prevalence, Screening, Intrapartum antibiotic prophylaxis, Perinatal outcomes
Subjects:	R Medicine > RG Gynecology and obstetrics > RG500 Obstetrics
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Obstetric & Gynecology
Depositing User:	Dr Nurul Mutmainnah Yusof
Date Deposited:	21 Nov 2025 17:43
Last Modified:	21 Nov 2025 17:43
Queue Number:	2025-11-Q139
URI:	http://irep.iium.edu.my/id/eprint/124584

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