The intricate nexus: the relationship between oxidative stress and inflammation in obesity

Abu Hanifah, Nabihah and Kuttulebbai Naina Mohamed Salam, Sirajudeen and Ahmad Affandi, Khairunisa and Abdullah, Nor Zamzila and Buyong, Zunariah and Abdul Rahim, Roslina and Ahmad, Hajar Fauzan (2025) The intricate nexus: the relationship between oxidative stress and inflammation in obesity. Malaysian Journal of Medicine and Health Sciences, 21 (5). pp. 365-374. ISSN 1675-8544 E-ISSN 2636-9346

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Abstract

Obesity, defined as excessive fat storage, is linked to chronic low-grade inflammation and increased reactive oxygen species (ROS) generation. Inflammatory cells, such as neutrophils and macrophages, produce ROS during oxidative bursts to attack infections. However, in obese people, increased ROS generation in hypertrophic and hypoxic adipose tissue maintains a chronic inflammatory state. ROS and Damage-Associated Molecular Patterns (DAMPs) generated by stressed adipocytes activate inflammatory pathways and transcription factors, including nuclear factor-kappa B (NF-κB). Identifying such mechanisms highlights the possibility of targeting ROS generation and inflammatory pathways to reduce chronic inflammation and enhance metabolic health in obesity. This review seeks to clarify the complex link between oxidative stress, inflammation, and obesity.

Item Type:	Article (Review)
Uncontrolled Keywords:	Reactive oxygen species, Oxidative stress, Inflammatory cytokine, Inflammation, Obesity
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine
Depositing User:	Prof.Dr. SIRAJUDEEN KUTTULEBBAI NAINAMOHAMED SALAM
Date Deposited:	15 Oct 2025 10:14
Last Modified:	15 Oct 2025 10:14
URI:	http://irep.iium.edu.my/id/eprint/123737

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