In-vivo antimicrobial and biocompatibility analysis of orthopaedic metal implant coated with silver (OMICS)

Mohd Jan, Nurul Hafiza and Zulkifly, Ahmad Hafiz and Ibrahim, Mohd Zulfadzli and Zainal Abdullah, Muhamad Ezham and Abdul Jalil, Rosnani and Abd Hamid, Zahana and Mohd Toff, Mohd Radzi (2023) In-vivo antimicrobial and biocompatibility analysis of orthopaedic metal implant coated with silver (OMICS). Malaysian Journal of Microscopy, 19 (1). pp. 238-246. ISSN 1823-7010 E-ISSN 2600-7444

	PDF - Published Version Restricted to Registered users only Download (577kB) | Request a copy
Preview	PDF - Supplemental Material Download (139kB) | Preview

Abstract

Implant-related infections and their management pose a major challenge in the orthopaedic field. The colonisation of bacteria and biofilm adhesion on implant surfaces may lead to infection at the implantation site. The infection risk may be overcome by applying OMICS as an alternative strategy in managing cases of implant-related infection. This study aims to evaluate OMICS's efficacy as an antibacterial implant and its biocompatibility properties in an animal model. All rabbits were implanted with OMICS as well as conventional plates and screws. The implanted tibia was excised en bloc and evaluated using microbiological swab and histological analysis for any effects of infection and its biocompatibility respectively. After three and six weeks of post-implantation, microbial analysis showed that no colonies were noted in OMICS groups compared to control. The histological analysis showed no bone reaction with no indication of the presence of microbial in both groups. No periosteal reaction was observed at the surrounding of the implanted area in both groups. This data showed that OMICS implant had antibacterial properties, biocompatible and provided good osteoconductivity comparable to conventional plates and screws. It can be concluded that the OMICS have potential to be served as antibacterial implant to prevent bacterial infection during implantation.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Implant-related infection, OMICS, antibacterial, biocompatibility
Subjects:	R Medicine > RD Surgery > RD701 Orthopedics
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation Kulliyyah of Medicine
Depositing User:	Mr. Mohd Zulfadzli Ibrahim
Date Deposited:	04 Jun 2025 14:51
Last Modified:	04 Jun 2025 14:51
URI:	http://irep.iium.edu.my/id/eprint/121344

Actions (login required)

View Item