The effect of Cinnamtannin B1 on cell proliferation and glucose uptake of 3T3-L1 cells

Bakhtiar, M. Taher and Abdul Majid, Fadzilah Adibah and Sarmidi, Mohamad Roji (2007) The effect of Cinnamtannin B1 on cell proliferation and glucose uptake of 3T3-L1 cells. Natural Product Communications, 2 (1). pp. 61-66. ISSN 1934-578X

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Abstract

The effects of cinnamtannin B1 on cell proliferation and glucose uptake of 3T3-L1 cells were examined. Cinnamtannin B1 promoted cell proliferation of 3T3-L1 adipocytes at a concentration range between 0.11-0.17 mM. The effect of cinnamtannin B1 on cellular 2-deoxy-D-[1-3H] glucose uptake in differentiated 3T3-L1 adipocytes, following treatment with a 0.11 mM concentration of cinnamtannin B1 for 15, 30 and 60 minutes, was an increase in the glucose uptake from a basal value to 702.0,1111.0 and 2226.0 cpm, respectively (p<0.005). The comparable glucose uptakes with insulin treatment were 660.0, 1039.0 and 2135.0 cpm, respectively. Wortmannin and cytochalasin B were found to inhibit cinnamtannin B1-stimulated glucose uptake, but sodium orthovanadate increased the glucose uptake.

Item Type:	Article (Journal)
Additional Information:	5209/12083
Uncontrolled Keywords:	cinnamtannin B1; cell proliferation; glucose uptake; 3T3-L1 cells
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr Muhammad Taher
Date Deposited:	15 Jul 2013 08:53
Last Modified:	09 Dec 2014 08:26
URI:	http://irep.iium.edu.my/id/eprint/12083

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