In vitro inhibitory effect of Rubraxanthone isolated from Garcinia psrvifolia on platelet- Activating factor receptor binding

Jantan, Ibrahim and Md Pisar, Mazura and Idris, Muhammad Sum and Bakhtiar, M. Taher and Mat Ali, Rasadah (2002) In vitro inhibitory effect of Rubraxanthone isolated from Garcinia psrvifolia on platelet- Activating factor receptor binding. Planta Medica, 68. pp. 1133-1134. ISSN 0032-0943

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Abstract

Rubraxanthone and isocowanol isolated from Garcinia parvifolia Miq. were investigated for their inhibitory effects on platelet-activating factor (PAF) binding to rabbit platelets using 3H-PAF as a ligand. Rubraxanthone showed a strong inhibition with IC 50 value of 18.2 microM. The IC 50 values of macluraxanthone, 6-deoxyjacareubin, 2-(3-methylbut-2-enyl)-1,3,5-trihydroxyxanthone, 2-(3-methylbut-2-enyl)-1,3,5,6-tetrahydroxyxanthone and 1,3,5-trihydroxy-6,6'-dimethylpyrano(2',3':6,7)-4-(1,1-dimethylprop-2-enyl)-xanthone were also determined for comparison. In the course of our study on structure-activity relationship of xanthones, the results revealed that a geranyl group substituted at C-8 was beneficial to the binding while a hydroxylated prenyl group at C-4 resulted in a significant loss in binding to the PAF receptor.

Item Type:	Article (Journal)
Additional Information:	5209/12052
Uncontrolled Keywords:	In vitro inhibitory
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr Muhammad Taher
Date Deposited:	15 Jul 2013 08:42
Last Modified:	09 Dec 2014 08:29
URI:	http://irep.iium.edu.my/id/eprint/12052

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