Camellia, Vita and Fitri, Fasihah Irfani and Ichwan, Muhammad and Sari, Dina Keumala and Effendy, Elmeida and Rambe, Aldy Safruddin and Ilyas, Syafruddin and Juliandi, Juliandi and Khatib, Alfi and Amin, Mustafa Mahmud and Rusda, Muhammad (2024) The effect of chronic administration of Amphetamine-Type stimulants on oxidative stress and inflammation in Wistar rats. Baghdad Science Journal, 21 (7). pp. 2237-2245. ISSN 2078-8665 E-ISSN 2411-7986
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Abstract
This study aims to determine the effect of chronic administration of amphetamine-type stimulants at varying doses on inflammation and oxidative stress in Wistar rats. They were given methylphenidate and divided into 4 treatment groups. Furthermore, simple random grouping was carried out to divide the samples into 5 groups, each consisting of 9 rats. These groups included rats given only distilled water as the controls, as well as those given methylphenidate at doses of 10 mg/kg BW, 20 mg/kg BW, and 40 mg/kg BW for 4 weeks as the experimental groups. Statistical analysis was then performed using GraphPad Prism to compare the effects of oxidative stress, systemic inflammation, BDNF, and spatial memory of the Wistar rats. Chronic administration of stimulants led to a significant decrease in glutathione peroxidase levels as well as an increase in the release of IL-6 and tumor necrosis factor-α compared to the control group. Based on the results, the pathways involved in cognitive impairment, which were related to the use of amphetamine-type stimulants played a role in addressing the detrimental effect of substance abuse and their comorbidities
Item Type: | Article (Journal) |
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Additional Information: | Alfi Khatib is the first IIUM author |
Uncontrolled Keywords: | amphetamine-type stimulants, glutathione peroxidase, IL-6, inflammation, oxidative stress, tumor necrosis factor-α |
Subjects: | R Medicine > RS Pharmacy and materia medica |
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry Kulliyyah of Pharmacy |
Depositing User: | Dr. Alfi Khatib |
Date Deposited: | 23 Dec 2024 10:36 |
Last Modified: | 23 Dec 2024 10:36 |
URI: | http://irep.iium.edu.my/id/eprint/116952 |
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