Siahaan, Salmon Charles and Santoso, Budi and Ismayani, Kanti and Yuwono, Natalia and Md Aris, Mohd Aznan (2024) The effect of docosahexaenoic acid (DHA) supplementation on total antioxidant capacity (TAC), superoxide dismutase (SOD), and interleukin-6 levels in underweight pregnant women. Majalah Obstetri & Ginekologi, 32 (3). pp. 181-188. ISSN 0854-0381 E-ISSN 2598-1013
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Abstract
Objective: Underweight pregnant women face oxidative stress and inflammation, increasing their risk of intrauterine growth restriction (IUGR) and preterm birth. This study investigates the effects of DHA supplementation on Total Antioxidant Capacity (TAC), Superoxide Dismutase (SOD), and Interleukin-6 (IL-6) in underweight pregnant women, along with the correlation between DHA and these markers. Materials and Methods: This experimental pre-test/post-test study focused on underweight pregnant women in the Made District, Surabaya, Indonesia. Eligible participants were in their second or third trimester, had a BMI below 18.5, and were taking DHA regularly. Exclusion criteria included early pregnancy (gestational age < 14 weeks), BMI above 18.5, irregular DHA intake, and withdrawal from the study. The study ran from July to December 2023, using non-probability sampling to select participants. Blood samples were collected before and after two months of DHA supplementation. Results: Following the intervention, TAC levels demonstrated a noteworthy increase (p < 0.05). SOD levels also exhibited a significant difference (p <0.05), and IL-6 levels showed a significant change (p < 0.05). A strong and positive correlation (r = 0.718) was observed between the increased TAC and SOD levels. DHA influenced both TAC and IL-6, with a significant relationship between TAC and IL-6 (p < 0.01). Furthermore, elevated SOD levels were associated with a decrease in IL-6 levels (p < 0.01). The correlation coefficient value of 0.718 between changes in SOD and TAC indicated a robust positive correlation. Conclusion: The findings suggest that DHA supplementation in underweight pregnant women positively affects oxidative stress and inflammation markers, improving TAC, SOD, and IL-6 levels.
| Item Type: | Article (Journal) |
|---|---|
| Additional Information: | 4632/116667 |
| Uncontrolled Keywords: | DHA, Pregnancy complication, Antioxidant, Superoxide dismutase, Interleukin-6, Maternal health |
| Subjects: | R Medicine > RG Gynecology and obstetrics |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Medicine Kulliyyah of Medicine > Department of Family Medicine (Effective: 1st January 2011) |
| Depositing User: | Prof Dr Mohd Aznan Md Aris |
| Date Deposited: | 13 Dec 2024 08:32 |
| Last Modified: | 13 Dec 2024 08:32 |
| URI: | http://irep.iium.edu.my/id/eprint/116667 |
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