Isolation and characterization of ssDNA aptamers against BipD antigen of Burkholderia pseudomallei

Selvam, Kasturi and Najib, Mohamad Ahmad and Khalid, Muhammad Fazli and Yunus, Muhammad Hafiznur and A. Wahab, Habibah and Harun, Azian and Zainulabid, Ummu Afeera and Mustaffa, Khairul Mohd Fadzli and Ismail, Aziah (2024) Isolation and characterization of ssDNA aptamers against BipD antigen of Burkholderia pseudomallei. Analytical Biochemistry, 695. pp. 1-11. ISSN 0003-2697 E-ISSN 1096-0309

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Abstract

Melioidosis is difficult to diagnose due to its wide range of clinical symptoms. The culture method is time-consuming and less sensitive, emphasizing the importance of rapid and accurate diagnostic tests for melioidosis. Burkholderia invasion protein D (BipD) of Burkholderia pseudomallei is a potential diagnostic biomarker. This study aimed to isolate and characterize single-stranded DNA aptamers that specifically target BipD.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Melioidosis; B. pseudomallei; BipD; ssDNA ; aptamers; SELEX
Subjects:	R Medicine > RC Internal medicine > RC111 Infectious and Parasitic Diseases
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Internal Medicine
Depositing User:	Asst. Dr. Ummu Afeera Zainulabid
Date Deposited:	05 Nov 2024 14:25
Last Modified:	05 Nov 2024 14:25
URI:	http://irep.iium.edu.my/id/eprint/115497

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