Nutrigenomics and Parkinson's disease

Razali, Khairiah and Algantri, Khaled and Loh, Su Peng and Cheng, Shi-Hui and Mohamed, Wael Mohamed Yousef (2024) Nutrigenomics and Parkinson's disease. In: Essential Guide to Neurodegenerative Disorders: Mechanistic, Diagnostic and Therapeutic Advances. Elsevier, London, UK, pp. 605-629. ISBN 9780443157028

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Abstract

Parkinson’s disease (PD) is a multifactorial disease, the development, and progression of which are influenced by multiple factors, including the genetic markups and the environment. Nutrition is considered one of the most robust environmental factors affecting PD as it can either induce or reduce disease susceptibility. Epigenetic mechanisms regulate gene expression through DNA methylation, histone modifications, and noncoding RNAs (ncRNAs) activity. Accumulating evidence from nutriepigenomics studies has reported altered epigenetic mechanisms in clinical and preclinical PD models and the potential role of nutrition in modifying the changes. In addition, through nutrigenetics and nutrigenomics studies, the diet-gene, and gene-diet interactions in relation to PD development and progression have been investigated. Herein, current findings on the roles of nutrition in epigenetic mechanisms underpinning PD development and progression are discussed. Besides, the potential of the personalized nutrition approach as adjuvant therapy for PD are also underlined.

Item Type:	Book Chapter
Uncontrolled Keywords:	Cellular neuroscience; Epigenetic mechanisms; Metabolism; Molecular genetics; Molecular mechanism of gene regulation; Nervous system disorder; Nutriepigenomics; Nutrigenetics; Nutrigenomics; Nutrition; Parkinson’s disease; Pathological process; Personalized nutrition.
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Dr Wael Mohamed
Date Deposited:	04 Dec 2024 14:27
Last Modified:	04 Dec 2024 16:07
URI:	http://irep.iium.edu.my/id/eprint/115365

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