Effect of tualang honey supplementation in weight reduction and dyslipidemia in high cholesterol diet induced obese rats

Abu Hanifah, Nabihah and Kuttulebbai Naina Mohamed Salam, Sirajudeen and Abdullah, Nor Zamzila and Buyong, Zunariah and Ahmad Affandi, Khairunisa and Abdul Rahim, Roslina and Ahmad, Hajar Fauzan (2024) Effect of tualang honey supplementation in weight reduction and dyslipidemia in high cholesterol diet induced obese rats. Medicine & Health, 19 (Suppl. 5). p. 22. E-ISSN 2289-5728

PDF (Meeting Abstract) - Published Version Restricted to Registered users only Download (379kB) | Request a copy

Abstract

Introduction: Obesity is a key risk factor for many chronic diseases. Malaysia records the highest prevalence of obesity in Southeast Asia. Tualang honey has been proven to treat other chronic diseases but its effect on weight reduction is not well-studied. This study aimed to investigate the effect of Tualang honey (TH) supplementation on body weight and lipid profile in 12% high cholesterol diet (HCD) induced obesity rat model. Materials and method: Forty male Sprague-Dawley rats were divided into 5 groups with their respective diet for 12 weeks followed by respective treatment for the following 6 weeks. The groups are: Group 1 (normal diet), Group 2 (normal diet and TH 3.0g/kg), Group 3 (12% HCD), Group 4 (12% HCD and TH 3.0 g/kg), and Group 5 (12% HCD and Orlistat 10 mg/kg). Their body weight was measured weekly. At the end of the study, blood was collected for lipid profile via retro-orbital bleeding. Results: We demonstrated a significantly lower final body weight of rats in Group 2 (328.25 + 25.49 g) compared to Group 1 (409.13 + 16.33 g) (p<0.001) and in Group 4 as compared to Group 3 (343.88 + 44.24 g vs 471.00 + 19.55 g, p<0.001). There is no significant difference in final body weight between Group 4 and Group 5 (343.88 + 44.24 g vs 354.25 + 32.27 g, p>0.05). The administration of TH also significantly reduces the cholesterol level in Group 4 compared to Group 3 (Med= 1.83 mmol/L, IQR= 0.68 vs Med=3.20 mmol/L, IQR= 0.80, p<0.05). The lowest concentration of triglycerides was recorded in Group 4 with a significant difference when compared to Group 3 (Med= 0.85 mmol/L, IQR= 0.28 vs Med= 1.45 mmol/L, IQR= 0.95, p=0.001). Conclusion: Tualang honey supplementation has been shown to reduce body weight, total cholesterol, and triglyceride levels in 12% of HCD-induced obese rats.

Item Type:	Article (Meeting Abstract)
Additional Information:	9547/114908
Uncontrolled Keywords:	Obesity; tualang honey; high cholesterol diet; dyslipidemia; body weight
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine Kulliyyah of Medicine > Department of Pathology & Lab Medicine
Depositing User:	Prof.Dr. SIRAJUDEEN KUTTULEBBAI NAINAMOHAMED SALAM
Date Deposited:	09 Oct 2024 12:52
Last Modified:	10 Oct 2024 17:26
URI:	http://irep.iium.edu.my/id/eprint/114908

Actions (login required)

View Item