Assessing lifetime occupational chrysotile inhalation exposure, respiratory symptoms, and lung cancer risk among brake maintenance workers in Malaysia

Yusof, Muhammad Zubir and Zahaba, Maryam and Mohd Aris, Mohd Shukri and Shafiee, Saiful 'Arifin and Abdul Hadi, Hazrin and Maghpor, Mohd Norhafsam and Noraini, Nor Mohd Razif (2024) Assessing lifetime occupational chrysotile inhalation exposure, respiratory symptoms, and lung cancer risk among brake maintenance workers in Malaysia. Toxicology and Industrial Health, 40 (11). pp. 596-604. ISSN 0748-2337 E-ISSN 1477-0393

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Abstract

This study aimed to estimate workers’ occupational lifetime exposure to chrysotile and examine the respiratory symptoms and lung cancer risk. A total of 112 workers were interviewed about their occupational histories. Exposure modeling using information on the determinants of exposure was used to estimate chrysotile emissions. The cumulative lifetime exposure was then assessed for each worker. Respiratory symptoms were obtained using a validated questionnaire. Lung cancer mortality rate was also predicted using a model. Almost all the workers were male and young (mean age = 30 years, SD = 7). The estimated lifetime occupational chrysotile inhalation exposure ranged from 0.0001 to 0.0486 f/mL.years (median = 0.0018 f/mL.years, IQR = 0.486). A high prevalence of cough symptom (11.7%), and low estimated cancer risk (<1%) were reported. In conclusion, the lung cancer risk among our cohort of workers was at a low level because of lower cumulative lifetime occupational chrysotile exposure.

Item Type:	Article (Journal)
Additional Information:	7773/114825
Uncontrolled Keywords:	Chrysotile, cumulative exposure, inhalation, lung cancer, respiratory symptoms
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RA Public aspects of medicine > RA1190 Toxicology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Community Medicine (Effective: 1st January 2011) Kulliyyah of Science Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Muhammad Zubir Yusof
Date Deposited:	03 Oct 2024 17:33
Last Modified:	04 Oct 2024 09:43
URI:	http://irep.iium.edu.my/id/eprint/114825

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