Unveiling the impact of Chlorella vulgaris supplementation on liver metabolisms of aged rats − A preclinical study

Ogechi Ekeuku, Sophia and Zainul Azlan, Nurhazirah and Mohd Yusof, Yasmin Anum and Tan, Jen Kit and Makpol, Suzana (2024) Unveiling the impact of Chlorella vulgaris supplementation on liver metabolisms of aged rats − A preclinical study. Journal of Functional Foods, 121. pp. 1-7. ISSN 1756-4646 E-ISSN 2214-9414

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Abstract

Chlorella vulgaris is renowned for its rich nutritional composition and has been associated with various health benefits. This study aimed to look into the effect of CV on liver metabolomes and metabolic pathways in aged Sprague Dawley (SD) rats. Three and 21-month-old male SD rats were divided into control and treated groups. Results showed that carbohydrates such as maltose/lactose and mannose/fructose were downregulated in old rats. These metabolites were downregulated in young rats supplemented with CV. Interestingly, taurine was upregulated in old rats, while the trend was reversed in old rats supplemented with CV at 300 mg/kg/d. The differentially expressed metabolites in different age groups and CV supplementation were mapped to starch and sucrose metabolism, galactose metabolism, and taurine and hypotaurine metabolism. Further research is needed to understand the long-term effects of CV supplementation on ageing and determine optimal dosage levels, especially regarding its potential to mitigate age-related diseases.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Chlorella vulgaris Ageing Liver Metabolomics Liquid Chromatography-Mass Spectrometry
Subjects:	Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Nursing > Department of Basic Medical Sciences for Nursing Kulliyyah of Nursing
Depositing User:	Asst Prof Dr Nurhazirah Zainul Azlan
Date Deposited:	02 Sep 2024 15:39
Last Modified:	02 Sep 2024 15:39
URI:	http://irep.iium.edu.my/id/eprint/114213

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