The inhibition of glucose absorption of seed and pericarp extracts of Pithecellobium jiringa on intestinal tissues preparation and their phytochemical profiles

Kasmuri, Abdul Razak and Mohd Hassan, Norazian and Arifin, Syamsul and Mehat, Isa and Mat Taib, Nurhaya (2010) The inhibition of glucose absorption of seed and pericarp extracts of Pithecellobium jiringa on intestinal tissues preparation and their phytochemical profiles. In: Malaysian Society of Pharmacology and Physiology.

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Abstract

The prevalence of diabetes in Malaysia within 10 years had doubled (Public Health Institute, 2008). The complication of the disease has more impact and burden on the health (ADA, 2008). The seriousness and the occurrence of the complications are closely related with tightly control hyperglycaemia (UKPDS,1998). Thus it is a better approach to screen substance that able to prevent postprandial hyperglycaemia that can cause fluctuating glucose levels i.e. to screen substance that able to decrease glucose absorption in GIT. Pithecellobium jiringa is already known to have antidiabetic property among Malaysians and used as its traditional remedy (Mohamed et al., 2005). A preliminary study showed that the plant has hypoglycaemic effect (Thevathasan, 1972). Radhiah et al. (2004) and Tungsarikarn et al. (2008) found that the plant has glucose lowering effect and the latter also proved the plant extract has an effect on alpha-glucosidase enzyme. On the other hand the seeds containing djenkolic acid which can cause djenkolism, which is a toxicity effect characterized by acute renal failure, urinary obstruction and spasmodic pain (Barceloux, 2009). The study was conducted with the aim at elaborating and reconciling the previous finding on the glucose lowering effect of P. jiringa. In order to make it more explorative, both of the seed and pericarp extracts of the plant were studied.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	3658/11407
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences Kulliyyah of Pharmacy > Department of Basic Medical Sciences
Depositing User:	Dr Abdul Razak Kasmuri
Date Deposited:	19 Dec 2011 17:43
Last Modified:	09 Dec 2022 10:53
URI:	http://irep.iium.edu.my/id/eprint/11407

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