Mohamed, Wael Mohamed Yousef and Eltantawi, Mohamed Abdelhalim and Agarwal, Vidhu and Bandres-Ciga, Sara and Makarious, Mary B and Mecheri, Yasser and Zewde, Yared Zenebe and Kamel, Walaa A and Al-Mubarak, Bashayer and Alzoubi, Karem H and Kissani, Najib and Alghamdi, Badrah Saeed and Sassi, Samia Ben and UNSPECIFIED (2024) The genetic architecture of Parkinson’s disease in the AfrAbia population: current state and future perspectives. Journal of Integrative Neuroscience, 23 (8). pp. 1-9. ISSN 0219-6352 E-ISSN 1757-448X
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Abstract
Over 80% of genetic studies in the Parkinson’s disease (PD) field have been conducted on individuals of European descent. There is a social and scientific imperative to understand the genetic basis of PD across global populations for therapeutic development and deployment. PD etiology is impacted by genetic and environmental factors that are variable by ancestry and region, emphasising the need for worldwide programs to gather large numbers of patients to identify novel candidate genes and risk loci involved in disease. Only a handful of documented genetic assessments have investigated families with PD in AfrAbia, which comprises the member nations of the Arab League and the African Union, with very limited cohort and case-control studies reported. This review article summarises prior research on PD genetics in AfrAbia, highlighting gaps and challenges. We discuss the etiological risk spectrum in the context of historical interactions, highlighting allele frequencies, penetrance, and the clinical manifestations of known genetic variants in the AfrAbian PD patient community.
| Item Type: | Article (Review) |
|---|---|
| Additional Information: | 7497/113988 |
| Uncontrolled Keywords: | AfrAbia; Parkinson’s disease; genetics; challenges; gaps; prospects |
| Subjects: | R Medicine > R Medicine (General) |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical |
| Depositing User: | Dr Wael Mohamed |
| Date Deposited: | 21 Aug 2024 08:20 |
| Last Modified: | 04 Sep 2024 15:05 |
| URI: | http://irep.iium.edu.my/id/eprint/113988 |
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