Flavonoids as potential wound-healing molecules: emphasis on pathways perspective

Zulkefli, Nabilah and Che Zahari, Che Nur Mazadillina and Sayuti, Nor Hafiza and Kamarudin, Ammar Akram and Saad, Norazalina and Hamezah, Hamizah Shahirah and Bunawan, Hamidun and Baharum, Syarul Nataqain and Mediani, Ahmed and Ahmed, Qamar Uddin and Harun @ Ismail, Ahmad Fahmi and Sarian, Murni Nazira (2023) Flavonoids as potential wound-healing molecules: emphasis on pathways perspective. International Journal of Molecular Sciences, 24. pp. 4607-4635. ISSN 1422-0067

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Abstract

Wounds are considered to be a serious problem that affects the healthcare sector in many countries, primarily due to diabetes and obesity. Wounds become worse because of unhealthy lifestyles and habits. Wound healing is a complicated physiological process that is essential for restoring the epithelial barrier after an injury. Numerous studies have reported that flavonoids possess wound-healing properties due to their well-acclaimed anti-inflammatory, angiogenesis, re-epithelialization, and antioxidant effects. They have been shown to be able to act on the wound healing process via expression of biomarkers respective to the pathways that mainly include Wnt/βcatenin, Hippo, Transforming Growth Factor-beta (TGF-β), Hedgehog, c-Jun N-Terminal Kinase (JNK), NF-E2-related factor 2/antioxidant responsive element (Nrf2/ARE), Nuclear Factor Kappa B (NF-κB), MAPK/ERK, Ras/Raf/MEK/ERK, phosphatidylinositol 3-kinase (PI3K)/Akt, Nitric oxide (NO) pathways, etc. Hence, we have compiled existing evidence on the manipulation of flavonoids towards achieving skin wound healing, together with current limitations and future perspectives in support of these polyphenolic compounds as safe wound-healing agents, in this review.

Item Type:	Article (Journal)
Uncontrolled Keywords:	wound healing; flavonoids; pathways; signaling; scar; natural products
Subjects:	Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr Qamar Uddin Ahmed
Date Deposited:	30 Jul 2024 14:54
Last Modified:	30 Jul 2024 15:27
URI:	http://irep.iium.edu.my/id/eprint/113496

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