Unlocking the Potential of Extracellular Vesicles as the Next Generation Therapy: Challenges and Opportunities

Che Shaffi, Syahidatulamali and Hairuddin, Omar Nafiis and Mansor, Siti Farizan and Tengku Zakaria, Tengku Muhamad Faris Syafiq and Yahaya, Badrul Hisham (2024) Unlocking the Potential of Extracellular Vesicles as the Next Generation Therapy: Challenges and Opportunities. Tissue Engineering and Regenerative Medicine, 21 (4). pp. 513-527. ISSN 17382696

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Abstract

BACKGROUND: Mesenchymal stem cells (MSCs) have undergone extensive investigation for their potential therapeutic applications, primarily attributed to their paracrine activity. Recently, researchers have been exploring the therapeutic potential of extracellular vesicles (EVs) released by MSCs. METHODS: MEDLINE/PubMed and Google scholar databases were used for the selection of literature. The keywords used were mesenchymal stem cells, extracellular vesicles, clinical application of EVs and challenges EVs production. RESULTS: These EVs have demonstrated robust capabilities in transporting intracellular cargo, playing a critical role in facilitating cell-to-cell communication by carrying functional molecules, including proteins, RNA species, DNAs, and lipids. Utilizing EVs as an alternative to stem cells offers several benefits, such as improved safety, reduced immuno- genicity, and the ability to traverse biological barriers. Consequently, EVs have emerged as an increasingly attractive option for clinical use. CONCLUSION: From this perspective, this review delves into the advantages and challenges associated with employing MSC–EVs in clinical settings, with a specific focus on their potential in treating conditions like lung diseases, cancer, and autoimmune disorders.

Item Type:	Article (Review)
Uncontrolled Keywords:	Mesenchymal stem cell, Extracellular vesicle, Clinical application, Stem cell therapy
Subjects:	Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Nursing Kulliyyah of Nursing > Department of Basic Medical Sciences for Nursing
Depositing User:	Asst Prof Tengku Faris
Date Deposited:	01 Jul 2024 08:13
Last Modified:	01 Jul 2024 08:13
URI:	http://irep.iium.edu.my/id/eprint/112863

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