Layer-by-layer coating of sesame oil in alginate-chitosan beads for enteric coating and sustained release

Abueta, Somaia and Ab. Hadi, Hazrina and Doolaanea, Abd Almonem and Mohammed Aloqyli, Abdullah (2024) Layer-by-layer coating of sesame oil in alginate-chitosan beads for enteric coating and sustained release. Journal of Pharmacy, 4 (1). pp. 23-32. E-ISSN 2773-5664

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Abstract

Introduction: Medical uses of alginate-chitosan beads have been growing widely in recent years due to their varied applications in pharmaceutical and biomedical technology. Moreover, a variety of research have used drug encapsulation in the alginate-chitosan matrix to facilitate the enteric coating and sustained release of therapeutic molecules. Sesame oil has various medical applications as it contains a significant amount of lignans, which enhance its antioxidant function and anti-inflammatory effects for external or internal medical uses. In addition, it has contributed to the treatment of several inflammatory bowel diseases. Layer-by-layer assembly provides an effective coating for drugs, improving the oil instability in the gastric media, preventing drug leakage, and elongating the release time for sesame oil. This study aims to encapsulate sesame oil in alginate-chitosan beads and to optimize the formulation for enteric coating. Method: Consuming sesame oil directly will not enable gastrointestinal tract to obtain the desired quantity of active ingredients in the oil due to the early degradation of oil. Therefore, the beads were prepared by using the external gelation method with layer-by-layer technique to provide multicoated layers. To illustrate, the usage of layer-by-layer assembly for the encapsulated alginate-sesame oil beads was accomplished by alginate and chitosan polysaccharides. A stability test was held to ensure the formulation stability during the study. In addition, the beads were characterized for particle size, roundness, and in-vitro drug release in different simulated buffers. Results: This study revealed that the layer-by-layer approach is a viable method to obtain a sesame oil alginate-chitosan bead formulation for enteric coating and sustained release. Formulation coated layer-by-layer provided a successful pass of the stomach system whereas 68% of cumulative drug release occurred in the intestine within 5 h. To illustrate, during 135 min uncoated beads showed a cumulative drug release of 65% while the same percentage was achieved in 255 min for coated beads. Conclusion: Sesame oil alginate-chitosan beads could be introduced as a promising carrier for encapsulating essential oils with favourable features.

Item Type:	Article (Journal)
Additional Information:	5589/112148
Uncontrolled Keywords:	Enteric coating, Sustained release, Layer-by-Layer, Sesame oil, Chitosan, Alginate.
Subjects:	R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy
Depositing User:	Ms Yasmin Mastura Mustafa Byrnes
Date Deposited:	10 May 2024 08:17
Last Modified:	10 May 2024 17:22
URI:	http://irep.iium.edu.my/id/eprint/112148

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