Anti-obesity potential of polygonum minus huds.: in vitro and in vivo evaluation

Arshad, Zulika and Sofian-Seng, Noor-Soffalina and Afzan, Adlin and Mohmad Misnan, Norazlan and Alias, Norsyuhada and Kamal, Norkhalida and Mediani, Ahmed and Abdul Rahman, Hafeedza (2024) Anti-obesity potential of polygonum minus huds.: in vitro and in vivo evaluation. International Journal of Food Science and Technology, 59 (10). pp. 7897-7906. ISSN 0950-5423 E-ISSN 1365-2621

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Abstract

Polygonum minus (PM) has a rich traditional usage for health benefits, yet its potential as a natural-based solution for obesity management remains unexplored. This study evaluated the antioxidant properties, inhibition of pancreatic lipase and α-glucosidase activities, and metabolite profiles of PM aerial extracts harvested at 8, 10, and 12 weeks using 1H NMR-based metabolomics. PM harvested at 12 weeks exhibited significant antioxidant and enzyme inhibition activities. NMR metabolomics unveiled nine major metabolites correlated to the bioactivities of 12-week PM. LC–MS/MS profiling enabled the identification of flavonoids and phenolic acids, with the majority having sulfate, gallate, and glycoside moieties. Notably, in vivo experiments demonstrated that rats treated with 200 mg kg−1 and 400 mg kg−1 PM exhibited significantly lower (P < 0.05) total body weight gain (39.03% and 52.59%, respectively) compared to negative control rats (69.95%), with the lower dose group also exhibiting reduced (P < 0.05) fasting blood glucose levels. This study highlights the potential of 12-week PM as a natural-based solution in obesity management.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Enzyme inhibition, high-fat diet, kesum, obesity prevention, plant metabolomics
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Depositing User:	Norsyuhada Alias
Date Deposited:	30 Sep 2024 09:47
Last Modified:	30 Sep 2024 09:52
URI:	http://irep.iium.edu.my/id/eprint/111732

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