Anti-hyperglycemic activity of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in alloxan induced diabetic rats

Umar, Abdulrashid and Ahmed, Qamar Uddin and Muhammad, Bala Yauri and Dogarai, Bashar Bello S. and Mat So'ad, Siti Zaiton (2010) Anti-hyperglycemic activity of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in alloxan induced diabetic rats. Journal of Ethnopharmacology, 131 (-). pp. 140-145. ISSN 0378-8741

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Abstract

Aim of the study: The present study was aimed to investigate the anti-diabetic potential of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in vivo with regard to prove its efficacy by local herbalists in the treatment of diabetes frailties. Materials and methods: Crude aqueous (AQ) and methanol (MEOH) extracts of the leaves of T. scandens L. were administered to both normal and alloxan induced diabetic male albino rats (Wistar strain). The blood glucose levels were measured at 0, 2, 4, 6 and 8 h after oral administration of AQ and MEOH extracts. Results: Significant reduction in glucose was observed in fasting blood glucose levels in the treated diabetic rats without causing any hypoglycemic effect compared to normal rats. Both polar extracts of the leaves of T. scandens L. exhibited significant anti-hyperglycemic activity at different doses and intervals. The highest anti-hyperglycemic effect (62.5%) was observed by the AQ extract at 0.25 g/kg body weight (b.w.) and MEOH extract (36.5%) at 0.5 g/kg b.w. after 8 h. The significant anti-hyperglycemic activity was found to be comparable with a known oral synthetic hypoglycemic drug, glibenclamide 0.25 mg/kg b.w. Conclusion: This study provides scientific evidence that the leaves of T. scandens L. have anti-diabetic efficacy and justifies its utility by local herbalists. However, more experiments at the clinical levels are required to confirm the utility of this plant by traditional practitioners in the management of diabetes mellitus. Keywords: Tetracera scandens L.; Dilleniaceae; Alloxan induced diabetic rats; Anti-hyperglycemic activity in vivo

Item Type:	Article (Journal)
Additional Information:	4921/11099
Uncontrolled Keywords:	Tetracera scandens L., dilleniaceae, alloxan induced diabetic rats, anti-hyperglycemic activity in vivo
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr Qamar Uddin Ahmed
Date Deposited:	19 Dec 2011 14:39
Last Modified:	27 Jul 2013 16:06
URI:	http://irep.iium.edu.my/id/eprint/11099

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