Sarmidi, Sardiana and Abdul Wahab, Azantee Yazmie and Azizan, Azha Syahril and Mubarak, Sarah and Yussoff, Noor Haliza (2022) Efficacy of antioxidant supplementation on sperm quality in men with oligoasthenoteratozoospermia. J Reprod Biotechnol Fertil. pp. 53-65. E-ISSN 2058-9158
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Abstract
Introduction Evidence of a positive relationship between the intake of antioxidant supplements and the improvement of sperm parameters has been reported mainly in European and American populations and very little in Asian populations. Hence, we aimed to investigate the association between antioxidant supplement intake (i.e., Profertil®) and sperm parameters in Malaysian men with Oligoasthenoteratozoospermia (OAT). Materials and methods: This is a single-centre retrospective study that investigated a total of 195 men with OAT whose female partners underwent ART treatment between 2016 and 2021. They were divided into 2 groups; a treatment group where male patients received two daily capsules of the antioxidant supplement (Profertil®) for 3 months (n = 92) and a control group where no micronutrient was given to the male partner (n = 103). Sperm parameters, including semen volume, sperm concentration, progressive motility, total motility, and morphology, were analyzed before and after treatment. A Kruskal-Wallis test was performed to compare the median levels of the sperm parameters. A Chi-square test was performed to compare the frequencies of normal morphology between the studied groups. Results: Demographic and baseline characteristics showed no significant differences except for the mean age of the husband and the etiology of infertility (p<0.05). When compared to their baseline sperm quality, men receiving Profertil® had highly significant increases in median sperm concentration (p<0.0001), motility (p<0.0001), progressive motility (p<0.0001), total sperm count (p<0.0001), total sperm motility (p=0.01) and total progressive motility (p<0.0001). Moreover, sperm abnormality of a total of 24 (26.1%) men improved after receiving Profertil® (p=0.013). Conclusion: Our data showed that antioxidants (Profertil®) have a positive effect on semen parameters in men with OAT
| Item Type: | Article (Journal) |
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| Uncontrolled Keywords: | antioxidants, efficacy, count, morphology, sperm, supplementation |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Allied Health Sciences Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011) Kulliyyah of Medicine Kulliyyah of Medicine > Department of Obstetric & Gynecology |
| Depositing User: | Dr Azantee Yazmie Abdul Wahab |
| Date Deposited: | 19 Jan 2024 16:41 |
| Last Modified: | 24 Jan 2024 11:39 |
| URI: | http://irep.iium.edu.my/id/eprint/110290 |
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