Frequency of significant steatosis and compensated advanced chronic liver disease among adults with chronic liver disease

Shahrani, Shahreedhan and Singh Gill, Sandeep and Sooi, Choong Yeong and Skantha, Ruben and Chandra Kumar, C. Vikneshwaran and Limun, Mohd Fairul and Nik Muhamad Affendi, Nik Arsyad and Chuah, Kee Huat and Khoo, Stanley and Rajaram, Ruveena Bhavani and Chan, Wah Keong and Mahadeva, Sanjiv (2023) Frequency of significant steatosis and compensated advanced chronic liver disease among adults with chronic liver disease. Journal of Gastroenterology and Hepatology, 38 (10). pp. 1818-1822. ISSN 0815-9319 E-ISSN 1440-1746

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Abstract

Background: With changes in the epidemiology and treatment of chronic liver disease (CLD), the impact of various etiologies of liver disease on steatosis and advanced fibrosis are uncertain. Methods: A retrospective study was conducted among liver disease patients of various etiologies undergoing transient elastography (TE) over a 9-year duration. Results: Data for 2886 patients were analyzed and had the following demographics: The median age was 60 (IQR: 45-69) years, 51% were males, and ethnicity was predominantly Chinese (52.5%), followed by Malays (34%) and Indians (12.3%). The median CAP score was 272 (IQR: 219-319) dB/m and the median liver stiffness measurement (LSM) score was 6.5 (IQR: 4.9-9.7) kPa. Hepatic steatosis occurred across the spectrum of etiologies of CLD. Among patients with steatosis, the most common etiologies were nonalcoholic fatty liver disease (NAFLD) at 62% and chronic hepatitis B (CHB) at 26.3%. TE findings suggestive of cACLD (10.1-15 kPa) and highly suggestive of cACLD (>15 kPa) were observed in 11.3% and 12.4% of patients, respectively. NAFLD was found to be the most common etiology for cases with suggestive of cACLD (47.2%) and highly suggestive of cACLD (41.5%). Conclusion: Hepatic steatosis is common in CLD, regardless of etiology. Compared with other etiologies, NAFLD is now the leading cause of cACLD.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Chronic liver disease; Hepatic steatosis; Liver fibrosis; Metabolic dysfunction-associated liver disease; Transient elastography.
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine
Depositing User:	Dr Nik Arsyad Nik Muhamad Affendi
Date Deposited:	19 Dec 2023 08:29
Last Modified:	19 Dec 2023 08:31
URI:	http://irep.iium.edu.my/id/eprint/108718

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