Paraoxonase1 activity and its phenotype in untreated hyperthyroid Malay patients

Afzan Ibrahim, Hanim and Ibrahim, Ismiza and Kuttulebbai Naina Mohamed Salam, Sirajudeen and Azraini Che Soh, Noor Azlin and Tuan Ismail, Tuan Salwani and Yaacob, Najib Majdi and Mohammed Jelani, Aniza (2022) Paraoxonase1 activity and its phenotype in untreated hyperthyroid Malay patients. Sapporo Medical Journal, 56 (6). pp. 1-13. ISSN 0036-472X

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Abstract

Paraoxonase 1 (PON 1) is an enzyme synthesized in the liver and is associated with high density lipoprotein (HDL) in the systemic circulation. It is an antioxidant in which prevents oxidative stress and inflammation.Since oxidative stress had been proven to be the complication of hyperthyroidism due to increase metabolic rate, this study is trying to look for the association between PON1 activities and phenotype in untreated hyperthyroid Malay patients. A total of 107 Malays subjects consisting of 55 untreated hyperthyroid patients (TSH<0.01 mU/L) and 52 healthy subjects were included.. The phenotype of the serum was determined by using the ratio of salt stimulation PON 1 activity to the arylesterase activity. The median difference of basal PON 1 activities level between untreated hyperthyroid compared to the healthy control was not statistically significant (p=0.23). There is no correlation between PON 1 activity and TSH (r=0.18, p=0.899) and free T4 (p=0.130). The most common PON 1 phenotype was AB followed by BB and then AA phenotype in Malay population. There is no significant correlation between free T4 and TSH with PON 1 activity in untreated hyperthyroid hence, PON 1 activity is not affected by thyroid status. AB is the most common phenotype in Malay population followed by BB phenotype in Malay population in Kelantan.

Item Type:	Article (Journal)
Uncontrolled Keywords:	oxidative stress, hyperthyroid, paraoxonase1, Malay, phenotype
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Prof.Dr. SIRAJUDEEN KUTTULEBBAI NAINAMOHAMED SALAM
Date Deposited:	01 Nov 2023 12:26
Last Modified:	01 Nov 2023 12:29
URI:	http://irep.iium.edu.my/id/eprint/107833

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