Mohamed, Wael Mohamed Yousef
(2023)
Parkinson’s genetics research on underrepresented AfrAbia populations: current state and future prospects.
American Journal of Neurodegenerative Disease, 12 (2).
pp. 23-41.
ISSN 2165-591X
Abstract
Parkinson’s disease (PD), the most common motoric neurodegenerative illness, has been extensively
researched to better understand its complex pathophysiology. Nearly 80% of genome-wide association studies have
been conducted on persons of European ancestry, indicating a lack of diversity in human genetics. Disparate representation may result in disparities that impede the equitable adoption of personalized medicine and may also limit
our knowledge of illness etiology. Even though Parkinson’s disease (PD) is a global affliction, the AfrAbia population
remains understudied. We conducted a dynamic and longitudinal bibliometric analysis to investigate existing studies on Parkinson’s disease genetics in the AfrAbia area and identify data gaps and possible new research avenues.
All PD papers concentrating on PD genetics were found using the search terms “Parkinson’s Disease”, “Genetics”,
and “Africa” in the PubMed/MEDLINE database. Only English publications published between 1992 and 2023
were chosen using filters. Original English-language research publications disclosing genetic results on Parkinson’s
disease in non-European Africans were examined for inclusion. Two sets of independent reviewers discovered and
extracted pertinent data. The bibliometric study was carried out using the R software packages Bibliometrix and
Biblioshiny. The narrowed search yielded 43 publications, all published between 2006 and 2022. Yet, after applying
filters and considering the inclusion requirements, the search results comprise just 16 original articles out of 43 articles. There were 27 articles eliminated. This study puts emphasis on the critical need for more diverse participant
demographics in Parkinson’s disease investigations. AfrAbia-PD-Genetic Consortium (AAPDGC) is GP2 initiative that
helps to represent AfrAbia PD genetics.
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