An in vivo implantation study in New Zealand white rabbits for granular hydroxyapatite

Zulkifly, Ahmad Hafiz and Khalid, Kamarul Ariffin and Aziz, Mohd Yusof and Mohamed Amin, Mohamed Azril and Awang, Mohd Shukrimi and Mohd Yusof, Nazri and Che Ahmad, Aminudin and Zakaria@Mohamad, Zamzuri and Fazan, Fazilah (2008) An in vivo implantation study in New Zealand white rabbits for granular hydroxyapatite. European Cells and Materials, 16 (supp 2). p. 55. ISSN 1473-2262

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Abstract

We developed hydroxyapatite (HA) granules made from local raw materials (GranuMaS™), which have been fabricated using a novel method (Patent (Pending) No. PI 2004 0748). GranuMaS™ have been fully characterized using X-ray diffraction, scanning electron microscopy, energy dispersive x-ray, Fourier transform infra-red spectroscopy and inductively coupled plasma methods. It has also been shown to comply with the ASTM F1185 - 88 (1993) specification standards. Biocompatibility studies have been performed on the product, which include neutral red cytotoxicity assay using cultured fibroblast and CRL-1427 osteoblast cells; MTT (Tetrazolium Salt) assay; cytotoxicity studies for apoptosis using Acridine Orange / Propidium Iodide (AO/PI) dual staining of V79 cells in DMEM; and COMET assay genotoxicity studies using L-929 (normal mouse epithelial) cells. An in vivo implantation study involving New Zealand White rabbits were carried out in the course of this study.

Item Type:	Article (Journal)
Additional Information:	2397/10382
Subjects:	R Medicine > RD Surgery > RD701 Orthopedics
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation
Depositing User:	Prof Dr Ahmad Hafiz Zulkifly
Date Deposited:	23 Jul 2013 15:44
Last Modified:	16 Dec 2013 08:42
URI:	http://irep.iium.edu.my/id/eprint/10382

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