Chitosan-modified nanocarriers as carriers for anticancer drug delivery: promises and hurdles

Alhodieb, Fahad Saad and Abul Barkat, Md and Abul Barkat, Harshita and Ab. Hadi, Hazrina and Khan, Muhammed Idreesh and Ashfaq, Fauzia and Rahman, Mohammad Akhlaquer and Hassan, Mohd Zaheen and UNSPECIFIED (2022) Chitosan-modified nanocarriers as carriers for anticancer drug delivery: promises and hurdles. International Journal of Biological Macromolecules, 217. pp. 457-469. ISSN 0141-8130 E-ISSN 1879-0003

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Abstract

With the advent of drug delivery, various polymeric materials are being explored to fabricate numerous nanocarriers. Each polymer is associated with a few characteristics attributes which further facilitate its usage in drug delivery. One such polymer is chitosan (CS), which is extensively employed to deliver a variety of drugs to various targets, especially to cancer cells. The desired properties like biological origin, bio-adhesive, biocompatibility, the scope of chemical modification, biodegradability and controlled drug release make it a highly rough after polymer in pharmaceutical nanotechnology. The present review attempts to compile various chemical modifications on CS and showcase the outcomes of the derived nanocarriers, especially in cancer chemotherapy and drug delivery.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Chitin Nanotechnology Biocompatibility Biodegradability Chemotherapy Nanoparticles Micelles Derivatives
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr Hazrina Ab Hadi
Date Deposited:	09 Jan 2023 10:36
Last Modified:	09 Jan 2023 10:38
URI:	http://irep.iium.edu.my/id/eprint/103081

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