A prospective multicenter randomized controlled trial to evaluate the efficacy of chitosan hydrogel paste in comparison to commercial hydroactive gel as a wound bed preparation

Mohd Nasir, Nur Azida and Mat Saad, Arman Zaharil and Bachok, Nor Sa’adah and Ab Rashid, Ahmad Hazri and Ujang, Zanariah and Noorsal, Kartini and Yusof, Norimah and Hashim, Kamaruddin and Mohd Nor, Fatimah and Imran, Farrah-Hani and Mohd Yusof, Nazri and Sharifudin, Mohd Ariff and Halim, Ahmad Sukari (2022) A prospective multicenter randomized controlled trial to evaluate the efficacy of chitosan hydrogel paste in comparison to commercial hydroactive gel as a wound bed preparation. Indian Journal of Plastic Surgery, 55. ISSN 0970-0358 E-ISSN 1998-376X

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Abstract

Background This clinical trial aimed to evaluate the clinical efficacy of chitosan derivative hydrogel paste (CDHP) as a wound bed preparation for wounds with cavities. Methods This study enrolled 287 patients, with 143 patients randomized into the CDHP group (treatment) and 144 patients randomized into the commercial hydro�active gel (CHG) group (control). The granulation tissue, necrotic tissue, patient comfort, clinical signs, symptoms, and patient convenience during the application and removal of the dressing were assessed. Results The study was completed by 111 and 105 patients from the treatment and control groups, respectively. Both groups showed an increasing mean percentage of wound granulation over time when the initial wound size and comorbidity were adjusted (F(10,198) =4.61; p < 0.001), but no significant difference was found between the groups (F(1,207)= 0.043; p ¼ 0.953). The adjusted mean percentage of necrotic tissue of both groups showed a significant decrease over time (F (10,235) = 5.65; p <0.001), but no significant differences were found between the groups (F (1,244)= 0.487; p ¼ 0.486). Conclusion CDHP is equivalent to CHG and is an alternative in wound management and wound bed preparation for wounds with cavities

Item Type:	Article (Journal)
Uncontrolled Keywords:	chitosan dressing, full-thickness wound, cavity wounds, granulation
Subjects:	R Medicine > RD Surgery
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation
Depositing User:	Nazri Mohd. Yusof
Date Deposited:	29 Dec 2022 14:33
Last Modified:	29 Dec 2022 14:46
URI:	http://irep.iium.edu.my/id/eprint/102581

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