Neurodegeneration and inflammation crosstalk: therapeutic targets and perspectives

Mohamed, Wael Mohamed Yousef and Kumar, Jaya and S.Alghamdi, Badrah and Soliman, Al-Hassan and Toshihide, Yamashita (2022) Neurodegeneration and inflammation crosstalk: therapeutic targets and perspectives. IBRO Neuroscience Reports, 14. pp. 95-110. ISSN 2667-2421

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Abstract

Glia, which was formerly considered to exist just to connect neurons, now plays a key function in a wide range of physiological events, including formation of memory, learning, neuroplasticity, synaptic plasticity, energy consumption, and homeostasis of ions. Glial cells regulate the brain's immune responses and confers nutritional and structural aid to neurons, making them an important player in a broad range of neurological disorders. Alzheimer's, ALS, Parkinson's, frontotemporal dementia (FTD), and epilepsy are a few of the neurodegenerative diseases that have been linked to microglia and astroglia cells, in particular. Synapse growth is aided by glial cell activity, and this activity has an effect on neuronal signalling. Each glial malfunction in diverse neurodegenerative diseases is distinct, and we will discuss its significance in the progression of the illness, as well as its potential for future treatment

Item Type:	Article (Journal)
Uncontrolled Keywords:	Neurons, Glial cells, Neurodegeneration, Immune system, Microglia
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Dr Wael Mohamed
Date Deposited:	20 Dec 2022 11:17
Last Modified:	20 Feb 2023 14:33
URI:	http://irep.iium.edu.my/id/eprint/102044

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