The assessment of interleukin-1 in chronic kidney disease patients with periodontitis following non-surgical periodontal therapy

Kassim, Nur Karyatee and Abdul Rahman, Nurul Aliya and Hanafi, Muhammad Hafiz and Zainuddin, Siti Lailatul Akmar and Kamarudin, Muhammad Imran and Ahmad, Farizan and Kuttulebbai Naina Mohamed Salam, Sirajudeen and Ibrahim, Hanim Afzan and Wan Ahmad, Wan Muhammad Amir (2022) The assessment of interleukin-1 in chronic kidney disease patients with periodontitis following non-surgical periodontal therapy. Malaysian Journal of Pathology, 44 (2). p. 338. ISSN 0126−8635

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Abstract

Introduction: Chronic kidney disease (CKD) and periodontitis have an impact on patient’s morbidity and mortality. Periodontitis increases the inflammatory burden, which has been shown to impair renal function by altering serum inflammatory levels. Interleukin-1 (IL-1) has immunomodulatory properties that affect immunological responses of the host. Little is known regarding IL-1 alteration in CKD patients after non-surgical periodontal therapy (NSPT). Therefore, this study was aimed to assess and compare the level of IL-1 at baseline and after receiving NSPT. Materials & Methods: The study included twenty CKD patients with periodontitis (Group 1), twenty non-CKD patients with periodontitis (Group 2) and twenty healthy subjects (Group 3). During each visit, a blood sample was collected and the serum IL-1 concentration was analysed using enzyme-linked immunosorbent assay. Results: Our findings showed that IL-1 level was significantly higher (p<0.05) in Group 1 [Mean (SD) = 0.91(0.39)]pg/ml as compared to Group 2 [Mean (SD)= 0.79(0.27)]pg/ml and Group 3 [Mean (SD) = 0.57(0.39)]pg/ml. Following NSPT, there was significant reduction (p<0.05) in IL-1 level in Group 1 and Group 2. The eGFR has improved from [Mean (SD)= 25.25 (9.93)] mL/min/1.73m2 to 30.3(11.73) mL/min/1.73m2 post NSPT. Discussion: This study found that CKD patients with periodontitis exhibited a more severe systemic inflammatory response than non-CKD patients and healthy subjects. NSPT reduced the inflammatory markers and delay the progression of CKD. IL-1 is a promising inflammatory marker for monitoring CKD progression. Therefore, multicentre and larger sample size studies are needed in the future.

Item Type:	Article (other)
Subjects:	R Medicine > R Medicine (General) R Medicine > RK Dentistry > RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Prof.Dr. SIRAJUDEEN KUTTULEBBAI NAINAMOHAMED SALAM
Date Deposited:	29 Dec 2022 15:59
Last Modified:	13 Jan 2023 12:18
URI:	http://irep.iium.edu.my/id/eprint/101378

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