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Cefuroxime Axetil loaded dispersed formulation for enhanced drug release and antibacterial activity

Salam, Moushumi Tabassoom and Kumar, Ashim and Salam, Md. Abdus and Ibne Wahed, Mir Imam and Barman, Ranjan Kumar (2022) Cefuroxime Axetil loaded dispersed formulation for enhanced drug release and antibacterial activity. Indian Journal of Pharmaceutical Education and Research, 56 (3). s454-s461. ISSN 0019-5464

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Aim: Aqueous solubility of drugs is a determining factor for bioavailability in systemic circulation and confronts in the unbeaten formulation of therapeutic agents. Cefuroxime axetil (CA) is a broad-spectrum β-lactamase cephalosporin that pertains to class II drugs under Biopharmaceutical Classification System (BCS) with poor aqueous solubility and high absorption permeability after oral administration. The objective of this current work was to achieve the enhanced solubility in water and subsequent antibacterial activity of CA loaded coarse dispersion (CCD) formulations. Materials and Methods: CCDs were prepared by anti-solvent precipitation method by blending CA with a carrier, Microcrystalline cellulose (MCC) at different ratios. In-vitro dissolution test using paddle method and antibacterial study against Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 25922) were carried out for both pure CA and CCDs for performance comparison. Results: Among the formulations, CCD-3 exhibited maximized dissolution rate by 1.67-fold higher than that of pure CA with the drug-carrier (CA: MCC) ratio of 1:3. Antibacterial activity of CCD-3 against S. aureus and E. coli was also found by 1.75-fold and 5.25-fold higher relative zone of inhibition (RZOI), respectively than that of pure drug. Conclusion: As an optimized formulation, CCD-3 is a promising to be a fruitful substitute to conventional dosage forms of CA for the modified dissolution rate and antibacterial potency. However, before its recommendation as a novel formulation validation study to point its pharmacokinetics, competence with in-vivo antibacterial property and safety is needed.

Item Type: Article (Journal)
Uncontrolled Keywords: Cefroxime axetil, Coarse dispersion, Solubility, Dissolution, Antibacterial activity.
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RM Therapeutics. Pharmacology > RM300 Drugs and their action
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Basic Medical
Depositing User: Prof. Dr. Md. Abdus Salam
Date Deposited: 12 Sep 2022 08:30
Last Modified: 12 Sep 2022 08:32
URI: http://irep.iium.edu.my/id/eprint/99924

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