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Alteration in the functional organization of the default mode network following closed non-severe traumatic brain injury

Abdul Rahman, Muhammad Riddha and Abd Hamid, Aini Ismafairus and Noh, Nor Azila and Omar, Hazim and Wen, Jia Chai and Idris, Zamzuri and Ahmad, Asma Hayati and Fitzrol, Diana Noma and Ab. Ghani, Ab. Rahman Izaini Ghani and Wan Mohamad, Wan Nor Azlen and Mohamed Mustafar, Mohamed Faiz and Hanafi, Muhammad Hafiz and Reza, Mohamed Faruque and Umar, Hafidah and Mohd Zulkifly, Mohd Faizal and Song, Yee Ang and Zakaria, Zaitun and Musa, Kamarul Imran and Othman, Azizah and Embong, Zunaina and Sapiai, Nur Asma and Kandasamy, Regunath and Ibrahim, Haidi and Abdullah, Mohd Zaid and Amaruchkul, Kannapha and Valdes-Sosa, Pedro and Luisa-Bringas, Maria and Biswal, Bharat and Songsiri, Jitkomut and Yaacob, Hamwira Sakti and Sumari, Putra and Jamir Singh, Paramjit Singh and Azman, Azlinda and Abdullah, Jafri Malin (2022) Alteration in the functional organization of the default mode network following closed non-severe traumatic brain injury. Frontiers in Neuroscience, 16. pp. 1-14. ISSN 1662-4548 E-ISSN 1662-453X

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Abstract

The debilitating effect of traumatic brain injury (TBI) extends years after the initial injury and hampers the recovery process and quality of life. In this study, we explore the functional reorganization of the default mode network (DMN) of those affected with non-severe TBI. Traumatic brain injury (TBI) is a wide-spectrum disease that has heterogeneous effects on its victims and impacts everyday functioning. The functional disruption of the default mode network (DMN) after TBI has been established, but its link to causal effective connectivity remains to be explored. This study investigated the differences in the DMN between healthy participants and mild and moderate TBI, in terms of functional and effective connectivity using resting-state functional magnetic resonance imaging (fMRI). Nineteen non-severe TBI (mean age 30.84 ± 14.56) and twenty-two healthy (HC; mean age 27.23 ± 6.32) participants were recruited for this study. Resting-state fMRI data were obtained at the subacute phase (mean days 40.63 ± 10.14) and analyzed for functional activation and connectivity, independent component analysis, and effective connectivity within and between the DMN. Neuropsychological tests were also performed to assess the cognitive and memory domains. Compared to the HC, the TBI group exhibited lower activation in the thalamus, as well as significant functional hypoconnectivity between DMN and LN. Within the DMN nodes, decreased activations were detected in the left inferior parietal lobule, precuneus, and right superior frontal gyrus. Altered effective connectivities were also observed in the TBI group and were linked to the diminished activation in the left parietal region and precuneus. With regard to intra-DMN connectivity within the TBI group, positive correlations were found in verbal and visual memory with the language network, while a negative correlation was found in the cognitive domain with the visual network. Our results suggested that aberrant activities and functional connectivities within the DMN and with other RSNs were accompanied by the altered effective connectivities in the TBI group. These alterations were associated with impaired cognitive and memory domains in the TBI group, in particular within the language domain. These findings may provide insight for future TBI observational and interventional research.

Item Type: Article (Journal)
Uncontrolled Keywords: default mode network; effective connectivity; functional connectivity; neuropsychology; traumatic brain injury.
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Information and Communication Technology
Kulliyyah of Information and Communication Technology

Kulliyyah of Information and Communication Technology > Department of Computer Science
Kulliyyah of Information and Communication Technology > Department of Computer Science
Depositing User: Dr Hamwira Yaacob
Date Deposited: 24 Jul 2022 20:38
Last Modified: 24 Jul 2022 20:38
URI: http://irep.iium.edu.my/id/eprint/98898

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