Evaluation of production cross-sections for theranostic 67Cu radionuclide via proton-induced nuclear reaction on 68Zn target

Samert K.I, Ali and Khandaker, Mayeen Uddin and Al-mugren, K.S. and Latif, Sk.A. and Bradley, D.A. and Okhunov, Abdurahim and Sulieman, Abdelmoneim Adam Mohamed (2021) Evaluation of production cross-sections for theranostic 67Cu radionuclide via proton-induced nuclear reaction on 68Zn target. Applied Radiation and Isotopes, 173. pp. 1-11. ISSN 0969-8043 E-ISSN 1872-9800

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Abstract

Copper–67 (T1/2 = 61.83 h, ) is a promising radionuclide for theranostic applications especially in radio immunotherapy. However, one of the main drawbacks for its application is related to its limited availability. Various nuclear reaction routes investigated in the last years can result in 67Cu production, although the use of proton beams is the method of choice taken into account in this work. The goal of this work is a revision of the cross-sections aimed at 67Cu yield, which were evaluated for the 68Zn(p,2p)67Cu reaction route up to 80 MeV proton energy. A well-defined statistical procedure, i.e., the Simultaneous Evaluation on KALMAN (SOK), combined with the least-squares concept, was used to obtain the evaluated data together with the covariance matrix. The obtained evaluated data were also compared to predictions provided by the nuclear reaction model codes TALYS and EMPIRE, and a partial agreement among them has been found. These data may be useful for both existing and potential applications in nuclear medicine, to achieve an improvement and validation of the various nuclear reaction models, and may also find applications in other fields (e.g., activation analysis and thin layer activation).

Item Type:	Article (Journal)
Additional Information:	6825/96184
Uncontrolled Keywords:	Radio immunotherapy 67Cu, β – γ emitter, SOK code, Evaluated data, Nuclear reaction, cross–section, TALYS and EMPIRE codes
Subjects:	Q Science > QC Physics
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering Kulliyyah of Engineering > Department of Science
Depositing User:	Dr. Abdurahim Okhunov
Date Deposited:	11 Jan 2022 10:35
Last Modified:	11 Jan 2022 10:39
URI:	http://irep.iium.edu.my/id/eprint/96184

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