Antibodies against citrullinated proteins in relation to periodontitis with or without rheumatoid arthritis: a cross-sectional study

Vaithilingam, Rathna Devi and Lew, Pit Hui and Rahman, Mohammad Tariqur and Safii, Syarida Hasnur and Baharuddin, Nor Adinar and Bartold, Peter Mark and Sockalingam, Sargunan and Abu Kassim, Noor Lide (2021) Antibodies against citrullinated proteins in relation to periodontitis with or without rheumatoid arthritis: a cross-sectional study. BMC Oral Health, 21 (1). ISSN 1472-6831

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Abstract

Background: Previous studies have reported conflicting fndings between serum anti-citrullinated protein antibodies (ACPA) levels in rheumatoid arthritis (RA) participants with and without periodontitis (Pd). This study aimed to analyse possible correlations between serum ACPA levels and clinical parameters in Pd and RA participants. Methods: Full mouth periodontal examination (probing pocket depth, clinical attachment levels, gingival bleeding index, visual plaque index) was conducted and serum samples obtained from 80 participants comprising RA, Pd, both RA and Pd (RAPd) and healthy individuals (HC). Erythrocyte sedimentation rates (ESR) and periodontal infamed surface area (PISA) were obtained. Serum samples were analysed for ACPA quantifcation using enzyme-linked immunosorbent assay (ELISA). Results: Median levels (IU/mL) of ACPA (interquartile range, IQR) in RAPd, RA, Pd and HC groups were 118.58(274.51), 102.02(252.89), 78.48(132.6) and 51.67(91.31) respectively. ACPA levels were significantly higher in RAPd and RA as compared to HC group (p<0.05). However, ACPA levels of any of the groups were not correlated with any clinical periodontal and RA parameters within the respective groups. Conclusions: At individual level, the amount of serum ACPA seem to have an increasing trend with the diseased condition in the order of RAPd>RA>Pd>HC. However, lack of any signifcant correlation between the serum ACPA levels with the clinical Pd and RA parameters warrants further studies to investigate the causal link between RA and Pd for such a trend. Further studies involving more infammatory biomarkers might be useful to establish the causal link between Pd in the development and progression of RA or vice versa.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Keywords: Anti-citrullinated protein antibodies (ACPA), Citrullination, Periodontitis, Rheumatoid arthritis
Subjects:	R Medicine > RK Dentistry > RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Education > Department of Language & Literacy
Depositing User:	Prof Dr Noor Lide Abu Kassim
Date Deposited:	29 Dec 2021 16:50
Last Modified:	29 Dec 2021 16:50
URI:	http://irep.iium.edu.my/id/eprint/95652

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