Sperm morphology and testis histological changes in 12% high cholesterol diet administered rats following Tualang honey supplementation and diet modifications

Hasan, Sakiinah and Abdul Rahim, Roslina and Alias, Mohd Afzal and Muhammad, Siti Aeshah @ Naznin and Abdullah, Nor Zamzila and Abdul Razak, Redzuan Nul Hakim (2021) Sperm morphology and testis histological changes in 12% high cholesterol diet administered rats following Tualang honey supplementation and diet modifications. Frontiers in Pharmacology. p. 203. ISSN 978-2-88971-008-9

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Abstract

Background: Hypercholesterolaemia is recognized as a factor associated with male infertility. However, currently, there is limited therapy available. Tualang honey (TH) is a type of Malaysian polyfloral wild honey produced by the rock bee (Apis dorsata) proven to exert both anti-inflammatory and anti-oxidative effects. Objective: This study aimed to determine the effects of TH coupled with diet modification on sperm morphology and testis histology of 12% high cholesterol diet (HCD) administered rats. Methodology: Fifteen rats were fed with HCD for 16 weeks. They were then divided into 3 groups. Group A rats were not treated and continued HCD as control. Group B rats were supplemented with TH (3.0g/kg) and continued HCD, while group C was given TH (3.0g/kg) but was changed to a normal diet for 4 weeks. Results: Compared to group A, group B, and C demonstrated significant improvement in both sperm morphology and Johnsen testicular scoring compared to group A (p<0.001). However, there are no significant changes in Johnsen testicular scoring between the groups. Conclusion: Diet modification in addition to TH supplementation may further improve male fertility in HCD rats as compared to TH alone. Based on our findings, there is a need to further explore the potential TH in improving male infertility associated with hypercholesterolaemia.

Item Type:	Article (other)
Uncontrolled Keywords:	High cholesterol diet, Tualang honey, Sperm morphology, Testis histology, Johnsen testicular scoring
Subjects:	Q Science > QP Physiology R Medicine > RB Pathology R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC620 Specialties of Internal Medicine-Nutritional Diseases R Medicine > RC Internal medicine > RC627 Specialties of Internal Medicine-Metabolic Diseases
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Dr ROSLINA ABDUL RAHIM
Date Deposited:	27 Dec 2021 14:32
Last Modified:	06 Apr 2022 09:41
URI:	http://irep.iium.edu.my/id/eprint/95290

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