Streptococcus salivarius K12 inhibits candida albicans aggregation, biofilm formation and dimorphism

Mokhtar, Munirah and Rismayuddin, Nurul Alia Risma and Mat Yassim, Aini Syahida and Ahmad, Hasna and Abdul Wahab, Ridhwan and Dashper, Stuart and Arzmi, Mohd Hafiz (2021) Streptococcus salivarius K12 inhibits candida albicans aggregation, biofilm formation and dimorphism. Biofouling, 37 (7). pp. 767-776. ISSN 0892-7014

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Abstract

Candida albicans causes candidiasis, particularly in immunocompromised patients. Streptococcus salivarius K12 (K12) is a probiotic isolated from a healthy oral cavity. The study aimed to determine the effect of K12 on C. albicans aggregation, biofilm formation and dimorphism. C. albicans ATCC MYA-4901, acquired immunodeficiency syndrome (AIDS) isolate (ALC2), and oral cancer isolate (ALC3) and K12 were used in the study. All C. albicans strains and K12 were grown in yeast peptone dextrose agar and brain heart infusion agar, respectively, prior to aggregation, biofilm and dimorphism assays. Auto-aggregation of C. albicans MYA-4901 and ALC2 was categorised as high, while the co-aggregation of the strains was low in the presence of K12. C. albicans total cell count decreased significantly when co-cultured with K12 compared with monocultured C. albicans biofilm (p<0.05). Inhibition of yeast-to-hyphae transition was also observed when co-cultured with K12. In conclusion, K12 inhibits C. albicans aggregation, biofilm formation and dimorphism.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Polymicrobial interactions; aggregation; biofilm; dimorphism; probiotic
Subjects:	Q Science > QR Microbiology R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Depositing User:	AP Ts Dr Mohd Hafiz Arzmi
Date Deposited:	20 Oct 2021 09:17
Last Modified:	20 Oct 2021 09:17
URI:	http://irep.iium.edu.my/id/eprint/93126

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