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The Effect of Processing Parameters on the Properties of Fish Gelatin Hydrolysate Nanoparticle

Subara, Deni and Jaswir, Irwandi (2021) The Effect of Processing Parameters on the Properties of Fish Gelatin Hydrolysate Nanoparticle. Journal of Science and Applicative Technology, 5 (1). pp. 17-24. E-ISSN 2581-0545

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Fish gelatin hydrolysate is a well- known fish by-product that is high in protein content. It is produced from by-product waste from the fish processing industry, which includes fish skin, head, and bones. Gelatin hydrolysates have recently received much attention due to its high protein content and bioactivity, which includes antioxidant, antimicrobial and antihypertensive activities. The transformation of gelatin hydrolysate into nanoparticles is believed to increase its economic value. Furthermore, reduction into nano-size increases the absorption characteristic of this material. Here, fish gelatin hydrolysate nanoparticles are prepared for the first time using desolvation method. The effects of concentration of gelatin hydrolysate, pH of solution, and acetone concentration on nanoparticle size are determined. The prepared gelatin hydrolysate nanoparticles were found to have spherical shape with sizes varying from 300-400 nm with a mean size of 408 ± 11.4 nm, zeta potential of -16.4 ± 1.2 mV and PDI 0.203 ± 0.07. This study showed that concentration of gelatin hydrolysate, pH and concentration of solvent have significant effects on nanoparticle size. The gelatin hydrolysate nanoparticles can be applied in the pharmaceutical industry for the encapsulation of drugs to facilitate delivery to target sites.

Item Type: Article (Journal)
Subjects: Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): International Institute for Halal Research and Training (INHART)
Depositing User: Prof. Dr. Irwandi Jaswir
Date Deposited: 04 Oct 2021 09:49
Last Modified: 04 Oct 2021 09:49
URI: http://irep.iium.edu.my/id/eprint/92656

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