In vitro antioxidant and antiproliferative activities of three Malaysian sea cucumber species

Althunibat, Osama Yousef and Hashim, Ridzwan and Bakhtiar, M. Taher and Mohd. Daud, Jamaludin and Ikeda, Masa-Aki and Ibrahim, Zali (2009) In vitro antioxidant and antiproliferative activities of three Malaysian sea cucumber species. European Journal of Scientific Research, 37 (3). pp. 376-387. ISSN 1450-216X

PDF (In vitro antioxidant and antiproliferative activities of three Malaysian sea cucumber species) Restricted to Registered users only Download (250kB) | Request a copy

Abstract

The antioxidant and antiproliferative activities of aqueous and organic extracts from three sea cucumber species Holothuria scabra, Holothuria leucospilota and Stichopus chloronotus were studied. The result showed that aqueous extract of H. leucospilota contains the highest level of total phenols (9.7 mg GAE/g), while the lowest level was obtained from organic extract of H. scabra (1.53 mg GAE/g). An aqueous extract of S. chloronotus was the most efficient extract in scavenging of DPPH free radical, giving IC50 = 2.13 mg/ml. The aqueous extracts (50mg/ml) of H. scabra, H. leucospilota and S. chloronotus exhibited high antioxidant activities (77.46%, 64.03% and 80.58%, respectively) against linoleic acid free radical. Only an aqueous extract of S. chloronotus inhibited growth of C33A (human cervical cancer) and A549 (human non-small lung carcinoma) cancer cells, giving IC50 equal to 10.0 µg/ml and 28.0 µg/ml, respectively. On the other hand, the dose dependent antiproliferative effects of all organic extracts studied were observed on C33A and A549 cancer cells. This study, therefore, revealed that all the three species of Malaysian sea cucumber are potential sources of natural antioxidant and anticancer agents.

Item Type:	Article (Journal)
Additional Information:	5465/903
Uncontrolled Keywords:	antioxidant, antiproliferative, Malaysian sea cucumber.
Subjects:	R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Science
Depositing User:	Ms Zati Atiqah Mohamad Tanuri
Date Deposited:	13 Jul 2011 15:01
Last Modified:	20 Jun 2017 15:47
URI:	http://irep.iium.edu.my/id/eprint/903

Actions (login required)

View Item