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Biomedical application of responsive ‘smart’ electrospun nanofibers in drug delivery system: A minireview

Kamsani, Nurul Huda and Haris@Harith, Muhammad Salahuddin and Pandey, Manisha and Taher, Muhammad and Rullah, Kamal (2021) Biomedical application of responsive ‘smart’ electrospun nanofibers in drug delivery system: A minireview. Arabian Journal of Chemistry, 14 (7). ISSN 1878-5352

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Abstract

Electrospinning is a versatile method for producing continuous nanofibers. It has since become an easy and cost-effective technique in the manufacturing process and drawn keen interests in most biomedical field applications. Nanofibers have garnered great attention in nanomedicine due to their resemblance with the extracellular matrix (ECM). Like nanoparticles, its unique characteristics of higher surface-to-volume ratio and the tunability of the polymers utilizing nanofiber have increased the efficiency in encapsulation and drug-loading capabilities. Smart or “stimuli-responsive” polymers have shown particular fascination in controlled release, where their ability to react to minor changes in the environment, such as temperature, pH, electric field, light, or magnetic field, distinguishes them as intelligent. Polymers are a popular material for the design of drug delivery carriers; consequently, various types of drugs, including antiviral, proteins, antibiotics, DNA and RNA, are successfully encapsulated in the pH-dependent nanofibers with smart polymers which is a polymer that can respond to change such as pH change, temperature. In this minireview, we discuss applications of smart electrospun pH-responsive nanofibers in the emerging biomedical developments which includes cancer drug targeting, oral controlled release, wound healing and vaginal drug delivery.

Item Type: Article (Review)
Additional Information: 9020/89982
Uncontrolled Keywords: Electrospinning; Nanofibers; pH-responsive polymer; Drug delivery
Subjects: R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Dr Kamal Rullah
Date Deposited: 25 May 2021 12:17
Last Modified: 25 Aug 2021 16:08
URI: http://irep.iium.edu.my/id/eprint/89982

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