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Metformin-induced severe enteropathy: a case report

Iman, Mohd Shahril and Che' Man, Mohamad and Muslim, Nurul Hassanah and Che Alhadi, Shahidah and Amiruddin, Salman (2021) Metformin-induced severe enteropathy: a case report. Journal of Critical Reviews, 8 (2). pp. 454-456. ISSN 2394-5125

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We highlighted a case of an elderly man with uncontrolled diabetes experienced unbearable chronic diarrhoea for 18 months with the extent of wearing diapers daily. He was having numerous investigation to exclude causes such as malignancy and other red flags chronic diarrhoea causes. His abdominal x-ray portrays extensive abnormal gas pattern at small and large bowel but no dilatation yet other examination tests were inconclusive. His symptoms gradually resolved and achieve full recovery after discontinued Metformin. Even though, metformin was widely use, the most common cause of chronic diarrhoea among diabetic patient is still metformin until proven otherwise. Hence, the necessary precaution should be practice as extent of reaction of metformin adverse drug reaction (ADR) to gastrointestinal tract vary commonly mild to moderate and rarely severe reaction. The delay of suspicion of metformin�induced enteropathy was significantly impaired his social life, burden with unnecessary invasive investigation and hinder the management of diabetes to achieve good glycaemic control. This case emphasizes on the crucial aspect of assessing drug history and attempt drug free-interval if suspicion of adverse drug reaction.

Item Type: Article (Case Report)
Additional Information: 6885/89708
Uncontrolled Keywords: chronic diarrhoea, Metformin adverse drug reaction, Metformin-induced enteropathy
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Family Medicine (Effective: 1st January 2011)
Kulliyyah of Medicine > Department of Surgery
Date Deposited: 07 May 2021 11:52
Last Modified: 10 May 2022 10:24
URI: http://irep.iium.edu.my/id/eprint/89708

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