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Leishmaniasis: biological understanding and beyond

Salam, Md. Abdus (2004) Leishmaniasis: biological understanding and beyond. Pakistan Journal of Medical Sciences, 20 (2). pp. 164-168. ISSN 1682-024X E-ISSN 1681-715X

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An attempt has been made to briefly review the literature regarding current molecular understanding of host parasite relationship in Leishmaniasis. Sequencing of genomes for both human and important microbes including Leishmania major are in progress. The genetic information from both human and parasite have led towards molecular understanding of the interaction between parasite virulence factors and the host response factors. Gene codes for natural resistance associated macrophage protein 1 (NRAMP1), which controls the susceptibility to Leishmania donovani, Salmonella typhimurium and Mycobacterium bovis has been cloned in both mice and human. Research into the host genetics of Leishmaniasis has revealed the fundamental immunological mechanisms determining outcome of infection. It has been shown very conclusively that Tumour Necrosis Factor Alpha (TNF a) MHC and T helper cells (Th) all are associated to determine the susceptibility or resistance to leishmanial infection. Biological insights regarding parasite virulence genes identified as part of the leishmania genome project may be specifically targeted for vaccines or designing drugs for new treatments.

Item Type: Article (Review)
Additional Information: 9217/87305
Uncontrolled Keywords: Leishmaniasis
Subjects: R Medicine > RC Internal medicine > RC111 Infectious and Parasitic Diseases
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Basic Medical
Depositing User: Prof. Dr. Md. Abdus Salam
Date Deposited: 07 Jan 2021 12:13
Last Modified: 07 Jan 2021 12:13
URI: http://irep.iium.edu.my/id/eprint/87305

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