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Amebic liver abscess is associated with malnutrition and low serum leptin level

Alam, Faisal and Salam, Md. Abdus and Mahmood, Iftekhar and Kabir, Mamun and Chowdhury, Sharif and Haque, Rashidul (2016) Amebic liver abscess is associated with malnutrition and low serum leptin level. Journal of Infectious Diseases & Therapy, 4 (5). pp. 1-4. ISSN 23320877

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Background and Objective: Amebic liver abscess (ALA), the most common form of extra-intestinal amebiasis is caused by the protozoan parasite E. histolytica. It is a prevalent parasitic infection in the northern region of Bangladesh for which hospital admission is required. The aim of this investigation was to explore the clinical spectrum of amebic liver abscess and its relationship with malnutrition and serum biomarker leptin. Methods: The study population included 90 hospitalized ALA patients and 90 healthy controls during the period of July 2012 to June 2015. Liver abscess was diagnosed initially by ultrasound imaging and amebic liver abscess was confirmed by detection of E. histolytica DNA in abscess aspirates using a Real Time PCR. Body Mass Index (BMI) was measured conventionally for nutritional status and serum leptin was estimated by ELISA. Results: Among the ALA cases (N=90), 37% had low BMI against only 3% of controls (N=90) [p<0.0001 at 95% CI]. About69 (76%) of low BMI patients had large or multiple liver abscess in comparison to 29% of standard BMI (p<0.0001 at 95% CI). Likewise, body fluid derangements such as edema, pleural effusion and ascites, either solitary or in combination were significantly higher (87% vs. 37%) among ALA with low BMI than standard BMI. Overwhelming majority of ALA patients 81(90%) was hypoleptinaemic. Conclusion: Malnutrition and low serum leptin are important associations in amebic liver abscess patients with significance in disease outcomes.

Item Type: Article (Journal)
Additional Information: 9217/86938
Uncontrolled Keywords: Amebic liver abscess; Malnutrition; Leptin
Subjects: R Medicine > RA Public aspects of medicine > RA643 Communicable Diseases and Public Health
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Basic Medical
Depositing User: Prof. Dr. Md. Abdus Salam
Date Deposited: 27 Dec 2020 15:45
Last Modified: 27 Dec 2020 15:45
URI: http://irep.iium.edu.my/id/eprint/86938

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