Effect ofco-solvent, temperature, pressure on asiaticoside content in Centella Asiatica using supercritical fluid extraction (P-RIGS19-028-0028)

Darnis, Deny Susanti and Bakhtiar, M. Taher (2020) Effect ofco-solvent, temperature, pressure on asiaticoside content in Centella Asiatica using supercritical fluid extraction (P-RIGS19-028-0028). Project Report. UNSPECIFIED. (Unpublished)

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Abstract

as wound-healing and also act as an antioxidant, antiaging and whitening agents due to the presence of asiaticoside. In this study, the extraction of asiaticoside from C. asiatica was done using Supercritical Fluid Extraction (SFE) method as it was believed to produce highly concentrated extracts with mild operating temperature and also reduce the elimination of hazardous solvent wastes. This research was focused on the effect of co-solvent percentage, pressure and temperature on the asiaticoside content extracted using SFE. The effects of co-solvent percentage, pressure and temperature on asiaticoside content extracted from C. asiatica using SFE were successfully analyzed using Two-Level Factorial response surface model experimental design. Besides, analysis of variance (ANOVA) at a p-value significance level of 0.05 was used to scrutinize the significance of the factors on the yield of asiaticoside. In Two-Level Factorial screening experiment, co-solvent, pressure and temperature were significantly influenced the yield of asiaticoside content. Moreover, the interaction effect between each factor were also found to be statistically significant and were varied during optimization of the factors, using contour map and response surface method. The optimal extraction conditions for asiaticoside content yield within the experimental range of the variables researched were at 9.96769 %, 79.998 °C and 10 MPa for co-solvent, temperature and pressure, respectively.

Item Type:	Monograph (Project Report)
Additional Information:	5641/86341
Uncontrolled Keywords:	Centella asiatica; extraction; asiaticoside; optimization; supercritical fluid extraction
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Deny Susanti Darnis
Date Deposited:	21 Dec 2020 10:33
Last Modified:	21 Dec 2020 10:33
URI:	http://irep.iium.edu.my/id/eprint/86341

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