Investigations of amphiphilic butylglyceryl-functionalized dextran nanoparticles for topical delivery

F. Bostanudin, Mohammad and Muhamad Noor, Noor S. and Sahudin, Shariza and Mat Lazim, Azwan and Suk, Fei Tan and Sarker, Md. Zaidul Islam (2020) Investigations of amphiphilic butylglyceryl-functionalized dextran nanoparticles for topical delivery. Journal of Applied Polymer Sciences, 38 (16). pp. 1-10. ISSN 0021-8995 E-ISSN 1097-4628

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Abstract

Toward the development of colloidal systems that can enhance transdermal permeation of hydrophilic actives, a material combining the non‐toxic of dextran with alkylglycerols permeation enhancing property has been designed. To this purpose, a range of amphiphilic butylglyceryl dextrans (DEX‐OX4) was synthesized via modification with n‐butylglycidyl ether with a degree of functionalization in the range 6.3%–35.7%. A reduced viscosity and an increased molecular weight of DEX‐OX4 were recorded when compared to the starting material. DEX‐OX4 was formulated into nanocarriers and loaded with α‐arbutin prior to characterization—the nanoparticles (180–220 nm size) were found to be close‐to‐spherical, stable at pH 5 and 7, with a loading capacity of 11.7%. Slower release of α‐arbutin from the nanoparticles was demonstrated when tested in acidic media. Lack of toxicity at application‐relevant concentrations and increased permeation were demonstrated by nanoparticles in vitro results against immortalized skin human keratinocytes cells (HaCaT).

Item Type:	Article (Journal)
Additional Information:	6605/85787
Uncontrolled Keywords:	drug delivery systems, biomaterials, polysaccharides
Subjects:	Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Professor Md. Zaidul Islam Sarker
Date Deposited:	11 Dec 2020 14:50
Last Modified:	04 Feb 2021 11:20
URI:	http://irep.iium.edu.my/id/eprint/85787

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